Medical University of Plovdiv, Plovdiv, Bulgaria.
Folia Med (Plovdiv). 2024 Aug 31;66(4):568-573. doi: 10.3897/folmed.66.e120391.
Primary mammary sarcomas are very rare, histologically heterogeneous non-epithelial malignant neoplasms. Primary undifferentiated pleomorphic sarcoma is a rare malignant mesenchymal tumor in the breast. It is characterized by marked cellular atypism and pleomorphism. Isolated cases with an aggressive course and poor prognosis have been commonly described in the literature. We present a rare case of a 62-year-old woman with an 18-cm solid tumor of the left breast, 6 months old, which grew rapidly during the last month. Physical examination and mammography revealed no enlarged lymph nodes in the left axilla. A total mastectomy was performed. The diagnosis of undifferentiated pleomorphic sarcoma is challenging due to the lack of specific immunohistochemical markers. It can only be made after excluding other types of soft tissue sarcomas. This report discusses the histopathological and immunohistochemical studies that were conducted. Our case is distinguished from others with the same diagnosis by the atypical clinical presentation, which is painless, and the spontaneous bleeding, as well as the large size of the tumor.
原发性乳腺肉瘤非常罕见，是组织学上异质性的非上皮性恶性肿瘤。原发性未分化多形性肉瘤是一种罕见的乳腺间叶性恶性肿瘤。其特征为显著的细胞异型性和多形性。文献中常描述具有侵袭性病程和不良预后的孤立病例。我们报告了 1 例罕见的 62 岁女性，左侧乳房有 18cm 实性肿瘤，6 个月前出现，近 1 个月迅速增大。体格检查和乳房 X 线摄影显示左侧腋窝无淋巴结肿大。行全乳切除术。由于缺乏特异性免疫组化标志物，未分化多形性肉瘤的诊断具有挑战性。只有在排除其他类型的软组织肉瘤后才能做出诊断。本报告讨论了进行的组织病理学和免疫组织化学研究。我们的病例与其他具有相同诊断的病例不同，表现为无痛、自发性出血和肿瘤体积较大。
