Shenoy Thripthi Nagesh, Abdul Salam Abdul Ajees
Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Crit Rev Food Sci Nutr. 2024 Sep 11:1-26. doi: 10.1080/10408398.2024.2398636.
Breast cancer remains a leading cause of cancer-related mortality among women worldwide. One of its defining features is resistance to apoptosis, driven by aberrant expression of apoptosis-related proteins, notably the overexpression of anti-apoptotic Bcl-2 proteins. These proteins enable breast cancer cells to evade apoptosis and develop resistance to chemotherapy, underscoring their critical role as therapeutic targets. Diet plays a significant role in breast cancer risk, potentially escalating or inhibiting cancer development. Recognizing the limitations of current treatments, extensive research is focused on exploring bioactive compounds derived from natural sources such as plants, fruits, vegetables, and spices. These compounds are valued for their ability to exert potent anticancer effects with minimal toxicity and side effects. While literature extensively covers the effects of various dietary compounds in inducing apoptosis in cancer cells, comprehensive information specifically on how dietary bioactive compounds modulate anti-apoptotic Bcl-2 protein expression in breast cancer is limited. This review aims to provide a comprehensive understanding of the interaction between Bcl-2 proteins and caspases in the regulation of apoptosis, as well as the impact of dietary bioactive compounds on the modulation of anti-apoptotic Bcl-2 in breast cancer. It further explores how these interactions influence breast cancer progression and treatment outcomes.
乳腺癌仍然是全球女性癌症相关死亡的主要原因之一。其显著特征之一是对细胞凋亡产生抗性，这是由凋亡相关蛋白的异常表达驱动的，尤其是抗凋亡Bcl-2蛋白的过表达。这些蛋白使乳腺癌细胞能够逃避细胞凋亡并产生化疗抗性，凸显了它们作为治疗靶点的关键作用。饮食在乳腺癌风险中起着重要作用，可能会加剧或抑制癌症发展。鉴于目前治疗方法的局限性，广泛的研究集中在探索源自植物、水果、蔬菜和香料等天然来源的生物活性化合物。这些化合物因其能够以最小的毒性和副作用发挥强大的抗癌作用而受到重视。虽然文献广泛涵盖了各种膳食化合物在诱导癌细胞凋亡方面的作用，但关于膳食生物活性化合物如何具体调节乳腺癌中抗凋亡Bcl-2蛋白表达的全面信息有限。本综述旨在全面了解Bcl-2蛋白与半胱天冬酶在细胞凋亡调节中的相互作用，以及膳食生物活性化合物对乳腺癌中抗凋亡Bcl-2调节的影响。它进一步探讨了这些相互作用如何影响乳腺癌的进展和治疗结果。
