Evidence for an anaphylactic reaction-induced gastric acid secretion from the isolated stomach of the mouse.

Under in vitro circumstances, ovalbumin, administered serosally, caused a definite acid secretory response in the isolated whole stomach of sensitized mice. Acid secretion induced by challenge was inhibited by cimetidine or by pretreatment with disodium cromoglycate. It remained, however, unchanged by mepyramine or atropine. It is likely that a local histamine release caused by an anaphylactic reaction of type I might be involved in the pathogenesis of certain kinds of digestive diseases, i.e. peptic ulcer.