• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

哇巴因抑制Na⁺,K⁺-ATP酶对小鼠离体胃组胺和氨甲酰甲胆碱酸分泌反应的不同影响

Differential effects of Na+, K(+)-ATPase inhibition by ouabain on acid secretory responses to histamine and bethanechol in the mouse isolated stomach.

作者信息

Horie S, Yano S, Watanabe K

机构信息

Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan.

出版信息

Br J Pharmacol. 1994 May;112(1):87-92. doi: 10.1111/j.1476-5381.1994.tb13034.x.

DOI:10.1111/j.1476-5381.1994.tb13034.x
PMID:8032667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1910292/
Abstract
  1. The effect of Na+,K(+)-ATPase inhibition by ouabain on gastric acid secretion was studied in the mouse isolated whole stomach preparation. 2. Ouabain caused a transient enhancement of histamine-induced gastric acid secretion followed by an inhibitory phase. On the other hand, ouabain caused a rapid reduction of bethanechol-stimulated acid secretion without an enhancement phase. 3. In dibutyryl cyclic AMP-induced acid secretion, ouabain led to a transient increase in acid secretion followed by a fall, as was seen with the histamine stimulation. Ouabain caused a rapid reduction of A23187-induced acid secretion. 4. Ouabain by itself increased basal acid secretion, and thereafter slowly suppressed the acid secretion. 5. Atropine inhibited both the ouabain-induced enhancement of the stimulated gastric acid secretion and the ouabain-induced stimulation of basal acid secretion. 6. The present study showed that Na+,K(+)-ATPase inhibition by ouabain caused a phasic enhancement of the stimulated gastric acid secretion through release of endogenous acetylcholine when the secretagogues act via an intracellular cyclic AMP pathway. It also inhibited the stimulated acid secretion irrespective of secretagogues, probably through its inhibitory effect on Na+,K(+)-ATPase in the gastric parietal cell.
摘要
  1. 在小鼠离体全胃标本中研究了哇巴因抑制Na⁺,K⁺-ATP酶对胃酸分泌的影响。2. 哇巴因引起组胺诱导的胃酸分泌短暂增强，随后进入抑制阶段。另一方面，哇巴因使氨甲酰甲胆碱刺激的胃酸分泌迅速减少，无增强阶段。3. 在二丁酰环磷腺苷诱导的胃酸分泌中，哇巴因导致胃酸分泌短暂增加，随后下降，这与组胺刺激时所见相同。哇巴因使A23187诱导的胃酸分泌迅速减少。4. 哇巴因本身增加基础胃酸分泌，此后缓慢抑制胃酸分泌。5. 阿托品抑制哇巴因诱导的刺激胃酸分泌增强以及哇巴因诱导的基础胃酸分泌刺激。6. 本研究表明，当促分泌剂通过细胞内环磷腺苷途径起作用时，哇巴因抑制Na⁺,K⁺-ATP酶通过释放内源性乙酰胆碱引起刺激胃酸分泌的阶段性增强。它也抑制刺激的胃酸分泌，而与促分泌剂无关，可能是通过其对胃壁细胞中Na⁺,K⁺-ATP酶的抑制作用。

相似文献

1
Differential effects of Na+, K(+)-ATPase inhibition by ouabain on acid secretory responses to histamine and bethanechol in the mouse isolated stomach.哇巴因抑制Na⁺,K⁺-ATP酶对小鼠离体胃组胺和氨甲酰甲胆碱酸分泌反应的不同影响
Br J Pharmacol. 1994 May;112(1):87-92. doi: 10.1111/j.1476-5381.1994.tb13034.x.
2
Neurogenic stimulation of gastric acid secretion by the Na+, K(+)-ATPase inhibitor ouabain in mouse isolated stomach.在小鼠离体胃中，钠钾ATP酶抑制剂哇巴因对胃酸分泌的神经源性刺激作用
Gen Pharmacol. 1996 Jul;27(5):905-9. doi: 10.1016/0306-3623(95)02055-1.
3
Inhibitory effect of ouabain on in vitro and in vivo gastric acid secretion in the frog and the rat.哇巴因对青蛙和大鼠体内外胃酸分泌的抑制作用。
Experientia. 1984 Aug 15;40(8):809-12. doi: 10.1007/BF01951965.
4
The mechanism of action of omeprazole--a survey of its inhibitory actions in vitro.奥美拉唑的作用机制——对其体外抑制作用的综述
Scand J Gastroenterol Suppl. 1985;108:37-51.
5
Effects of SCH 32651 on resting and stimulated acid secretion in guinea-pig isolated fundic mucosa.SCH 32651对豚鼠离体胃底黏膜静息和刺激状态下胃酸分泌的影响。
Br J Pharmacol. 1984 Sep;83(1):75-82. doi: 10.1111/j.1476-5381.1984.tb10121.x.
6
Metiamide and stimulated acid secretion from the isolated non-distended and distended mouse stomach.甲硫米特与离体未扩张和扩张小鼠胃的刺激酸分泌。
J Physiol. 1977 Apr;266(2):327-46. doi: 10.1113/jphysiol.1977.sp011770.
7
Effects of drugs acting on Cl(-)-HCO3- and Na(+)-H+ exchangers on acid secretion in the rat gastric mucosa sheet preparation.作用于Cl(-)-HCO3-和Na(+)-H+交换体的药物对大鼠胃黏膜片制备中酸分泌的影响。
Eur J Pharmacol. 1992 Dec 8;229(1):15-9. doi: 10.1016/0014-2999(92)90280-h.
8
Effect of omeprazole on gastric acid secretion by the rat isolated stomach.
Pharmacol Res Commun. 1986 Mar;18(3):257-71. doi: 10.1016/0031-6989(86)90123-2.
9
Stimulatory effect of dibutyryl cyclic GMP on acid secretion in mouse isolated stomach and on histamine release in gastric mucosal cells.二丁酰环磷酸鸟苷对小鼠离体胃胃酸分泌及胃黏膜细胞组胺释放的刺激作用。
J Physiol Paris. 2000 Jan-Feb;94(1):25-9. doi: 10.1016/s0928-4257(99)00107-2.
10
Effects of cyclic AMP, ouabain and furosemide on ion transport in isolated canine gastric mucosa.环磷酸腺苷、哇巴因和呋塞米对离体犬胃黏膜离子转运的影响。
J Physiol. 1980 Dec;309:29-43. doi: 10.1113/jphysiol.1980.sp013491.

本文引用的文献

1
Effect of ouabain on acid secretion and electrolyte content of frog gastric mucosa.哇巴因对蛙胃黏膜酸分泌及电解质含量的影响。
Proc Soc Exp Biol Med. 1962 Jul;110:613-5. doi: 10.3181/00379727-110-27595.
2
The inhibitory effect of strophanthidin on secretion by the isolated gastric mucosa.毒毛花苷对离体胃黏膜分泌的抑制作用。
J Gen Physiol. 1959 Jul 20;42(6):1233-9. doi: 10.1085/jgp.42.6.1233.
3
Inhibition of gastric acid secretion in vivo and in vitro by an inhibitor of Cl(-)-HCO3- exchanger, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid.Cl(-)-HCO3-交换体抑制剂4,4'-二异硫氰基芪-2,2'-二磺酸在体内和体外对胃酸分泌的抑制作用
J Pharmacol Exp Ther. 1993 Jun;265(3):1313-8.
4
Comparative effects of cimetidine and famotidine on the vagally stimulated acid secretion in the isolated mouse whole stomach.
Jpn J Pharmacol. 1993 Mar;61(3):229-36. doi: 10.1254/jjp.61.229.
5
Ouabain is secreted by the adrenal gland in awake dogs.
Am J Physiol. 1993 Mar;264(3 Pt 1):E413-9. doi: 10.1152/ajpendo.1993.264.3.E413.
6
Effects of 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, an inhibitor of Cl(-)-HCO3- exchanger, on stress-induced gastric lesions in rats.
Res Commun Chem Pathol Pharmacol. 1993 Jan;79(1):117-20.
7
Lack of involvement of [Ca2+]i in the external Ca(2+)-independent release of acetylcholine evoked by veratridine, ouabain and alpha-latrotoxin: possible role of [Na+]i.细胞内钙离子浓度（[Ca2+]i）未参与藜芦碱、哇巴因和α- 拉托罗毒素诱发的乙酰胆碱非依赖细胞外钙离子释放：细胞内钠离子浓度（[Na+]i）的可能作用
J Physiol Paris. 1993;87(1):43-50. doi: 10.1016/0928-4257(93)90023-m.
8
An isolated mammalian stomach preparation for studying the effect of substances on gastric acid secretion.一种用于研究物质对胃酸分泌影响的离体哺乳动物胃制备物。
Arzneimittelforschung. 1981;31(6):998-1000.
9
A circulating inhibitor of (Na+ + K+)ATPase associated with essential hypertension.一种与原发性高血压相关的循环性（钠+钾）ATP酶抑制剂。
Nature. 1982 Dec 16;300(5893):650-2. doi: 10.1038/300650a0.
10
Na+, K+-ATPase of the canine mesenteric artery.犬肠系膜动脉的钠钾ATP酶
Fed Proc. 1982 Apr;41(6):2101-5.