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抗逆转录病毒治疗（ART）联合治疗的 HIV 感染者中 1 型糖尿病发病机制：一个谜。

Mechanisms underlying the development of type 1 diabetes in ART-treated people living with HIV: an enigmatic puzzle.

机构信息

Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.

College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, China.

出版信息

Front Immunol. 2024 Aug 27;15:1470308. doi: 10.3389/fimmu.2024.1470308. eCollection 2024.

DOI:10.3389/fimmu.2024.1470308
PMID:39257582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11383789/
Abstract

The immunopathogenesis of HIV infection remains poorly understood. Despite the widespread use of effective modern antiretroviral therapy (ART), people living with HIV (PLWH) are known to develop several comorbidities, including type 1 diabetes (T1DM). However, the etiology and critical mechanisms accounting for the onset of T1DM in the preceding context remain unknown. This article proposes to address this topic in order to provide further understanding and future research directions.

摘要

HIV 感染的免疫发病机制仍不清楚。尽管广泛使用有效的现代抗逆转录病毒疗法 (ART)，但人们知道 HIV 感染者 (PLWH) 会发展出几种合并症，包括 1 型糖尿病 (T1DM)。然而，在这种情况下导致 T1DM 发病的病因和关键机制仍不清楚。本文旨在探讨这一主题，以提供进一步的了解和未来的研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11383789/159a6073be66/fimmu-15-1470308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11383789/6bdb7a366fb0/fimmu-15-1470308-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11383789/e558ed388816/fimmu-15-1470308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11383789/159a6073be66/fimmu-15-1470308-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11383789/6bdb7a366fb0/fimmu-15-1470308-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11383789/017f2a51e5b5/fimmu-15-1470308-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11383789/e558ed388816/fimmu-15-1470308-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da0d/11383789/159a6073be66/fimmu-15-1470308-g004.jpg

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本文引用的文献

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Macrophages: Key Cellular Players in HIV Infection and Pathogenesis.巨噬细胞：HIV 感染和发病机制中的关键细胞因子。
Viruses. 2024 Feb 13;16(2):288. doi: 10.3390/v16020288.
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The Potential of Clostridium butyricum to Preserve Gut Health, and to Mitigate Non-AIDS Comorbidities in People Living with HIV.丁酸梭菌在维持肠道健康和减轻 HIV 感染者非艾滋病合并症方面的潜力。
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HIV-associated gut microbial alterations are dependent on host and geographic context.
与HIV相关的肠道微生物改变取决于宿主和地理环境。
Nat Commun. 2024 Feb 5;15(1):1055. doi: 10.1038/s41467-023-44566-4.
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The immunology of type 1 diabetes.1 型糖尿病的免疫学。
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5
Prevalence of autoimmune diseases in an admixed population of patients with type 1 diabetes: a multicenter study in Brazil.1型糖尿病患者混合人群中自身免疫性疾病的患病率：巴西的一项多中心研究。
Diabetol Metab Syndr. 2024 Jan 31;16(1):31. doi: 10.1186/s13098-024-01274-3.
6
Immune activation and inflammation in lactating women on combination antiretroviral therapy: role of gut dysfunction and gut microbiota imbalance.哺乳期接受联合抗逆转录病毒治疗的妇女的免疫激活和炎症：肠道功能障碍和肠道微生物群落失衡的作用。
Front Immunol. 2023 Nov 16;14:1280262. doi: 10.3389/fimmu.2023.1280262. eCollection 2023.
7
Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients.肠道微生物群失调促进HIV感染患者的黏膜屏障损伤和免疫损伤。
Can J Infect Dis Med Microbiol. 2023 Oct 28;2023:3080969. doi: 10.1155/2023/3080969. eCollection 2023.
8
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Cell Rep. 2023 Nov 28;42(11):113336. doi: 10.1016/j.celrep.2023.113336. Epub 2023 Nov 1.
9
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10
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Chin Med J (Engl). 2023 Sep 20;136(18):2147-2155. doi: 10.1097/CM9.0000000000002493. Epub 2023 May 29.