Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Center for Plastic & Reconstructive Surgery, Department of Orthopedics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
Front Endocrinol (Lausanne). 2024 Aug 27;15:1364368. doi: 10.3389/fendo.2024.1364368. eCollection 2024.
The causality of autoimmune diseases with frailty has not been firmly established. We conducted this Mendelian randomization (MR) study to unveil the causal associations between autoimmune diseases with frailty.
A MR analyses were performed to explore the relationships between autoimmune disease and frailty, using summary genome-wide association statistics.
Through a comprehensive and meticulous screening process, we incorporated 46, 7, 12, 20, 5, and 53 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for hypothyroidism, hyperthyroidism, rheumatoid arthritis (RA), type 1 diabetes (T1D), multiple sclerosis (MS), and overall autoimmune disease, respectively. Our analysis revealed that hypothyroidism (OR = 1.023, 95% CI: 1.008-1.038, p = 0.0015), hyperthyroidism (OR = 1.024, 95% CI: 1.004-1.045, p = 0.0163), RA (OR = 1.031, 95% CI: 1.011-1.052, p = 0.0017), T1D (OR = 1.011, 95% CI: 1.004-1.017, p = 0.0012), and overall autoimmune disease (OR = 1.044, 95% CI: 1.028-1.061, p = 5.3210^-8) exhibited a positive causal effect on frailty. Conversely, there may be a negative causal association between MS (OR = 0.984, 95% CI: 0.977-0.992, p = 4.8710^-5) and frailty. Cochran's Q test indicated heterogeneity among IVs derived from hypothyroidism, hyperthyroidism, T1D, and overall autoimmune diseases. The MR-Egger regression analyzes revealed an absence of horizontal pleiotropy in any of the conducted analyses.
This study elucidates that hypothyroidism, hyperthyroidism, RA, T1D, and overall autoimmune disease were linked to an elevated risk of frailty. Conversely, MS appears to be associated with a potential decrease in the risk of frailty.
自身免疫性疾病与虚弱之间的因果关系尚未得到明确证实。我们进行了这项孟德尔随机化（MR）研究，以揭示自身免疫性疾病与虚弱之间的因果关系。
使用汇总全基因组关联统计数据，进行 MR 分析以探索自身免疫性疾病与虚弱之间的关系。
通过全面细致的筛选过程，我们将 46、7、12、20、5 和 53 个单核苷酸多态性（SNP）分别作为甲状腺功能减退症、甲状腺功能亢进症、类风湿关节炎（RA）、1 型糖尿病（T1D）、多发性硬化症（MS）和整体自身免疫性疾病的工具变量（IV）。我们的分析表明，甲状腺功能减退症（OR=1.023，95%CI：1.008-1.038，p=0.0015）、甲状腺功能亢进症（OR=1.024，95%CI：1.004-1.045，p=0.0163）、RA（OR=1.031，95%CI：1.011-1.052，p=0.0017）、T1D（OR=1.011，95%CI：1.004-1.017，p=0.0012）和整体自身免疫性疾病（OR=1.044，95%CI：1.028-1.061，p=5.3210^-8）对虚弱表现出正向因果关系。相反，MS（OR=0.984，95%CI：0.977-0.992，p=4.8710^-5）与虚弱之间可能存在负向因果关系。Cochran's Q 检验表明，甲状腺功能减退症、甲状腺功能亢进症、T1D 和整体自身免疫性疾病中 IV 存在异质性。MR-Egger 回归分析表明，在任何进行的分析中都不存在水平偏倚。
本研究表明，甲状腺功能减退症、甲状腺功能亢进症、RA、T1D 和整体自身免疫性疾病与虚弱风险升高相关。相反，MS 似乎与虚弱风险降低有关。
