Wyrwoll Margot J, Steingröver Johanna
Centre for Regenerative Medicine University of Edinburgh 5 Little France Drive EH16 4UU Edinburgh United Kingdom.
Centre of Medical Genetics University and University Hospital of Münster Vesaliusweg 12-14 48149 Münster Germany.
Med Genet. 2024 Sep 6;36(3):179-188. doi: 10.1515/medgen-2024-2036. eCollection 2024 Sep.
For those affected, infertility is linked to impaired overall health and reduced life expectancy. In particular, infertile individuals bear an increased risk for cardiovascular disease (CVD) and different types of cancer, partially due to lifestyle differences and to genetic alterations that cause both infertility and an increased cancer risk. Genetic variants causing an increased CVD risk are more commonly found in infertile individuals, but their link to infertility remains unclear. Offspring of infertile couples, conceived via medically assisted reproduction, are as likely as their parents to exhibit or develop adiposity, hormonal alterations such as insulin resistance, and infertility. The effects on health of subsequent generations are completely unclear.
对于那些受影响的人来说，不孕不育与整体健康受损和预期寿命缩短有关。特别是，不孕不育个体患心血管疾病（CVD）和不同类型癌症的风险增加，部分原因是生活方式的差异以及导致不孕不育和癌症风险增加的基因改变。导致心血管疾病风险增加的基因变异在不孕不育个体中更常见，但其与不孕不育的联系仍不清楚。通过医学辅助生殖受孕的不孕不育夫妇的后代，与他们的父母一样，有可能表现出或发展出肥胖、激素改变（如胰岛素抵抗）和不孕不育。对后代健康的影响完全不清楚。
