Mandal Apurba, Rai Rohit, Mandal Arif Ali, Dhar Prodyut, Banerjee Samya
Department of Chemistry, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh, 221005, India.
School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh, 221005, India.
Chem Asian J. 2024 Dec 16;19(24):e202400943. doi: 10.1002/asia.202400943. Epub 2024 Oct 30.
Three novel polypyridyl-Co(III)-vitamin B complexes viz., [Co(CF-phtpy)(SBVB)]Cl (Co1), [Co(anthracene-tpy)(SBVB)]Cl (Co2), [Co(NMe-phtpy)(SBVB)]Cl (Co3), where 4'-(4-(trifluoromethyl)phenyl)-2,2':6',2''-terpyridine=CF-phtpy, 4'-(anthracen-9-yl)-2,2':6',2''-terpyridine=anthracene-tpy;, 4-([2,2':6',2''-terpyridin]-4'-yl)-N,N-dimethylaniline=NMe-phtpy, (E)-5-(hydroxymethyl)-4-(((2-hydroxyphenyl)imino)methyl)-2-methylpyridin-3-ol=HSBVB were successfully developed for aPDT (antibacterial photodynamic therapy) applications. Co1-Co3 exhibited an intense absorption band at ca. 435-485 nm, which is attributed to ligand-to-metal charge transfer and was beneficial for antibacterial photodynamic therapy. The distorted octahedral geometry of the complexes with CoNO core was evident from the DFT study. The visible light absorption ability and good photo-stability of Co1-Co3 made them good photosensitizers for aPDT. Co1-Co3 displayed significant antibacterial responses against gram-positive (S. aureus) and gram-negative (E. coli) bacteria upon light exposure (10 J cm 400-700 nm) and showed MIC values between 0.01-0.005 μg mL. The aPDT activities of these complexes were due to their ability to damage bacterial cell membranes via ROS generation. Overall, this study shows the photo-triggered ROS-mediated bacteria-killing potential of Co(III) complexes.
成功开发了三种新型的聚吡啶基 - 钴（III）-维生素B配合物，即[Co(CF - phtpy)(SBVB)]Cl（Co1）、[Co(蒽 - tpy)(SBVB)]Cl（Co2）、[Co(NMe - phtpy)(SBVB)]Cl（Co3），其中4'-(4-(三氟甲基)phenyl)-2,2':6',2''-三联吡啶 = CF - phtpy，4'-(蒽 - 9 - yl)-2,2':6',2''-三联吡啶 = 蒽 - tpy，4 - ([2,2':6',2''-三联吡啶]-4'-基)-N,N - 二甲基苯胺 = NMe - phtpy，(E)-5-(羟甲基)-4 - (((2 - 羟基苯基)亚氨基)甲基)-2 - 甲基吡啶 - 3 - 醇 = HSBVB，用于抗菌光动力疗法（aPDT）应用。Co1 - Co3在约435 - 485 nm处表现出强烈的吸收带，这归因于配体到金属的电荷转移，有利于抗菌光动力疗法。从密度泛函理论（DFT）研究中可以明显看出具有CoNO核心的配合物的扭曲八面体几何结构。Co1 - Co3的可见光吸收能力和良好的光稳定性使其成为aPDT的良好光敏剂。Co1 - Co3在光照（10 J cm⁻²，400 - 700 nm）下对革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌）表现出显著的抗菌反应，最低抑菌浓度（MIC）值在0.01 - 0.005 μg mL⁻¹之间。这些配合物的aPDT活性归因于它们通过产生活性氧（ROS）破坏细菌细胞膜的能力。总体而言，这项研究表明了钴（III）配合物的光触发ROS介导的杀菌潜力。
