Universidade Estadual de Maringá, Departamento de Biotecnologia, Genética e Biologia Celular, Avenida Colombo, 5790, 87020-900 Maringá, PR, Brazil.
Universidade Unicesumar, Centro de Ciências da Saúde, Avenida Guedner, 1610, Jardim Acadêmico, 87050-900 Maringá, PR, Brazil.
An Acad Bras Cienc. 2024 Sep 9;96(suppl 1):e20231049. doi: 10.1590/0001-3765202420231049. eCollection 2024.
Nutritional insults early in life, such as during the suckling phase, are associated with phenotypic alterations and promote adverse permanent effects that impair the capacity to maintain energy balance in adulthood. This study aimed to evaluate the long-term effects of a low-protein (LP) diet during lactation on the metabolism and antioxidant systems of adult female rat offspring. Dams were fed a low-protein diet (4% protein) during the first two weeks of lactation or a normal-protein (NP) diet (20% protein) during the entire lactation period. The female offspring received a standard diet throughout the experiment. At 90 days of age, female LP offspring exhibited decreased body weight, feeding efficiency, and fat pad stores. The adult LP female offspring displayed brown adipose tissue hyperplasia without alterations in glucose homeostasis. The LP diet decreased liver triglyceride content and improved the antioxidant system compared to the NP group. The LP diet during the suckling phase promotes a lean phenotype and improves the hepatocyte antioxidant system in adult female offspring. Thus, the LP diet may play an important role in homeostasis and the prevention of metabolic damage.
生命早期的营养不足，如哺乳期，与表型改变有关，并导致不良的永久性影响，损害成年后维持能量平衡的能力。本研究旨在评估哺乳期低蛋白（LP）饮食对成年雌性大鼠后代代谢和抗氧化系统的长期影响。在哺乳期的前两周，母鼠喂食低蛋白（4%蛋白）饮食，而在整个哺乳期喂食正常蛋白（NP）饮食（20%蛋白）。雌性后代在整个实验过程中都接受标准饮食。在 90 天时，LP 雌性后代的体重、摄食效率和脂肪垫储存减少。成年 LP 雌性后代的棕色脂肪组织增生，但葡萄糖稳态没有改变。LP 饮食降低了肝脏甘油三酯含量，并改善了抗氧化系统，与 NP 组相比。哺乳期的 LP 饮食促进了瘦体型的形成，并改善了成年雌性后代的肝细胞抗氧化系统。因此，LP 饮食可能在维持体内平衡和预防代谢损伤方面发挥重要作用。
