Cohen M P, Klepser H
Biochem Biophys Res Commun. 1985 Jun 14;129(2):530-5. doi: 10.1016/0006-291x(85)90184-6.
The aldose reductase inhibitor Sorbinil affects several membrane-associated complexes including Na/K-ATPase activity, transport processes, and impulse propagation. These considerations, coupled with the drug's aromatic nature, suggested the possibility of direct interaction with cell membranes. In the present study, binding of [3H]-Sorbinil to isolated glomeruli was demonstrated. Binding is dose-dependent and saturable, and can be inhibited by increasing concentrations of unlabeled Sorbinil. These results may help explain the compound's diverse effects on membrane-associated processes.
