Department of Chemical & Biochemical Engineering, College of Engineering, Dongguk University, Seoul, South Korea.
Department of Chemical & Biochemical Engineering, College of Engineering, Dongguk University, Seoul, South Korea.
Adv Colloid Interface Sci. 2024 Nov;333:103301. doi: 10.1016/j.cis.2024.103301. Epub 2024 Sep 6.
Phenylboronic acid (PBA) is recognized as one of the most promising cancer cell binding modules attributed to its potential to form reversible and dynamic boronic ester covalent bonds. Exploring the advanced chemical versatility of PBA is crucial for developing new anticancer therapeutics. The presence of a specific Lewis acidic boron atom-based functional group and a Π-ring-connected ring has garnered increasing interest in the field of cancer immunotherapy. PBA-derivatized functional biomaterials can form reversible bonds with diols containing cell surface markers and proteins. This review primarily focuses on the following topics: (1) the importance and versatility of PBA, (2) different PBA derivatives with pKa values, (3) specific key features of PBA-mediated biomaterials, and (4) cell surface activity for cancer immunotherapy applications. Specific key features of PBA-mediated materials, including sensing, bioadhesion, and gelation, along with important synthesis strategies, are highlighted. The utilization of PBA-mediated biomaterials for cancer immunotherapy, especially the role of PBA-based nanoparticles and PBA-mediated cell-based therapeutics, is also discussed. Finally, a perspective on future research based on PBA-biomaterials for immunotherapy applications is presented.
苯硼酸（PBA）被认为是最有前途的癌细胞结合模块之一，归因于其形成可逆和动态硼酸酯共价键的潜力。探索 PBA 的先进化学多功能性对于开发新的抗癌疗法至关重要。基于特定路易斯酸性硼原子的功能基团和Π键连接环的存在，引起了癌症免疫治疗领域的越来越多的关注。PBA 衍生的功能生物材料可以与含有细胞表面标志物和蛋白质的二醇形成可逆键。本综述主要关注以下几个方面：（1）PBA 的重要性和多功能性，（2）具有不同 pKa 值的 PBA 衍生物，（3）PBA 介导的生物材料的特定关键特征，以及（4）用于癌症免疫治疗应用的细胞表面活性。强调了 PBA 介导的材料的特定关键特征，包括传感、生物粘附和凝胶化，以及重要的合成策略。还讨论了 PBA 介导的生物材料在癌症免疫治疗中的应用，特别是基于 PBA 的纳米粒子和 PBA 介导的基于细胞的治疗剂的作用。最后，提出了基于 PBA-生物材料用于免疫治疗应用的未来研究展望。
