Savrova O B, Medvedev D I
Biull Eksp Biol Med. 1985 Jun;99(6):738-40.
Autoradiographic and morphometric studies of the embryonal endbrain anlage of mice whose mothers were kept on the low-protein diet since the first day of pregnancy point to the retardation of the embryonal cerebral cortex histogenesis under the influence of alimentary deficiency. The structure of the endbrain anlage in 17-day-old embryos, that developed under the conditions of malnutrition, correlated with the earlier stages of embryogenesis in terms of the degree of maturity. The retardation of the neocortex development is caused by a fall in the rate of ventricular cell proliferation because of a 21% increase in the duration of the mitotic cycle. Analysis of the distribution pattern of intensely labeled neuronal nuclei in the neocortex of 20-day-old mice whose mothers were injected with 3H-thymidine on days 13 and 17 of pregnancy indicates that under the conditions of prenatal malnutrition the neurons in the appropriate layers of the brain cortex are formed at the later times as compared to normal.
对自怀孕第一天起就以低蛋白饮食饲养的小鼠胚胎端脑原基进行的放射自显影和形态测量研究表明，在营养缺乏的影响下，胚胎大脑皮层组织发生受到抑制。在营养不良条件下发育的17日龄胚胎的端脑原基结构，就成熟程度而言，与胚胎发育的早期阶段相关。新皮层发育的迟缓是由于有丝分裂周期持续时间增加21%，导致脑室细胞增殖速率下降所致。对在怀孕第13天和第17天给其母亲注射3H-胸腺嘧啶核苷的20日龄小鼠新皮层中强烈标记的神经元细胞核分布模式的分析表明，在产前营养不良的条件下，大脑皮层相应层中的神经元形成时间比正常情况晚。
