Xu Yang, Guo Cuixia, Zhou Chongqi, He Yonghong, Cao Ke, Li Defa
Department of Laboratory Medicine, Shenzhen Children's Hospital, Shenzhen, 518038, China.
School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, 350108, China.
Talanta. 2025 Jan 1;281:126845. doi: 10.1016/j.talanta.2024.126845. Epub 2024 Sep 10.
This study addresses the critical need for high purity chiral molecules in biological systems by overcoming the challenges associated with the quantitative detection of chiral molecules and their enantiomeric mixtures. We developed an innovative detection approach that leverages the two-dimensional information gleaned from natural optical rotation (NOR) and Faraday optical rotation (FOR) under magnetic fields in chiral molecules, combined with an ultrahigh-resolution weak measurement sensor. This novel weak measurement system achieves unparalleled accuracy in detecting spin angles, with a precision of 1.86 × 10. Notably, our method introduces no chemical reactions or interference with the substances under test. It offers enhanced discrimination capabilities through the dual-dimensional analysis of both natural and Faraday optical rotation, alongside a simple and compact sensor design. Conclusively, our study introduces a novel, high-precision, and multi-dimensional optical detection paradigm for chiral molecules. By incorporating Faraday rotation in the presence of a magnetic field, we expand the informational dimensionality accessible to the original weak measurement sensor, facilitating the quantitative analysis of chiral molecules and their enantiomers. This breakthrough not only furnishes a novel instrument for the exploration and development of chiral pharmaceuticals but also propels the advancement of weak measurement sensing technology forward.
本研究通过克服与手性分子及其对映体混合物定量检测相关的挑战，满足了生物系统中对高纯度手性分子的迫切需求。我们开发了一种创新的检测方法，该方法利用从手性分子在磁场下的自然旋光（NOR）和法拉第旋光（FOR）中收集的二维信息，并结合超高分辨率弱测量传感器。这种新型弱测量系统在检测自旋角方面实现了无与伦比的精度，精度为1.86×10。值得注意的是，我们的方法不引入化学反应，也不干扰被测物质。它通过对自然旋光和法拉第旋光的二维分析提供了增强的辨别能力，同时具有简单紧凑的传感器设计。总之，我们的研究为手性分子引入了一种新颖、高精度和多维的光学检测范式。通过在磁场存在下纳入法拉第旋转，我们扩展了原始弱测量传感器可获取的信息维度，便于对手性分子及其对映体进行定量分析。这一突破不仅为手性药物的探索和开发提供了一种新型仪器，还推动了弱测量传感技术的进步。
