Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, Department of Laboratory Animal Science, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200040, China.
Department of Neurosurgery, Huashan Hospital, Institute for Translational Brain Research, Department of Laboratory Animal Science, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200040, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China.
Immunity. 2024 Sep 10;57(9):2000-2002. doi: 10.1016/j.immuni.2024.08.006.
Our brain is not an immune-privileged island isolated from peripheries, but how non-neuronal brain cells interact with the peripheral system is not well understood. Wei et al. report that microglia in the hypothalamic paraventricular nucleus (PVN) with unique vasculature can detect ATP derived from hemodynamic disturbance. These microglia in the PVN regulate the response to hypertension via ATP-P2Y12-C/EBPβ signaling.
我们的大脑并非一个与外周隔绝的免疫特权孤岛，但非神经元脑细胞如何与外周系统相互作用还不是很清楚。Wei 等人报告说，具有独特血管系统的下丘脑室旁核（PVN）中的小胶质细胞可以检测到源自血流动力学紊乱的 ATP。这些 PVN 中的小胶质细胞通过 ATP-P2Y12-C/EBPβ信号调节对高血压的反应。
