Department of Physics, The Ohio State University, Columbus, OH, USA; Steve and Cindy Rasmussen Institute for Genomic Medicine, The Abigail Wexner Research Institute at the Nationwide Children's Hospital, Columbus, OH, USA.
Steve and Cindy Rasmussen Institute for Genomic Medicine, The Abigail Wexner Research Institute at the Nationwide Children's Hospital, Columbus, OH, USA; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA; Pelotonia Institute for Immuno-Oncology, College of Medicine, The Ohio State University, Columbus, OH, USA.
Immunity. 2024 Sep 10;57(9):2002-2004. doi: 10.1016/j.immuni.2024.08.012.
Intestinal macrophages play a key role in regulating immune tolerance in the gut. In this issue of Immunity, Mertens et al. uncover a mechanism for the establishment of memory in macrophage tolerance in the gut involving a bistable metabolic switch in macrophages and an intercellular positive feedback between macrophages and intestinal epithelial cells (IECs).
肠道巨噬细胞在调节肠道免疫耐受中发挥着关键作用。在本期《免疫》杂志中，Mertens 等人揭示了肠道巨噬细胞耐受中记忆形成的一种机制，涉及巨噬细胞中双稳态代谢开关和巨噬细胞与肠道上皮细胞（IEC）之间的细胞间正反馈。
