一种抗衰老疫苗：卡介苗让髓鞘再生失败“时光倒流”。

An anti-aging vaccine: BCG turns back the clock on remyelination failure.

机构信息

Department of Biomedical Sciences, section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

出版信息

Immunity. 2024 Sep 10;57(9):2005-2007. doi: 10.1016/j.immuni.2024.08.001.

DOI:10.1016/j.immuni.2024.08.001

PMID:39260352

Abstract

Aging leads to alterations that precipitate or aggravate several diseases that occur across our lifespan. In the CNS, aging affects the capacity to maintain and repair the myelin sheaths that protect axons and facilitate neuronal signaling. Tiwari et al. report aging-associated transcriptional responses in microglia after demyelination, which could be reversed by epigenetic remodeling after BCG vaccination.

摘要

衰老是导致几种在我们一生中发生的疾病恶化或加剧的原因。在中枢神经系统中，衰老会影响维持和修复髓鞘的能力，髓鞘保护轴突并促进神经元信号传递。Tiwari 等人报道了脱髓鞘后小胶质细胞中与衰老相关的转录反应，这种反应可以通过 BCG 疫苗接种后的表观遗传重塑来逆转。