Wang Jennifer Y, Swetter Susan M
Department of Dermatology/Pigmented Lesion and Melanoma Program, Stanford University Medical Center and Cancer Institute, Stanford, California, USA.
Department of Dermatology/Pigmented Lesion and Melanoma Program, Stanford University Medical Center and Cancer Institute, Stanford, California, USA.
Clin Dermatol. 2025 May-Jun;43(3):356-364. doi: 10.1016/j.clindermatol.2024.09.009. Epub 2024 Sep 10.
Primary dermal melanoma (PDM) is a rare subtype of melanoma with an estimated incidence of <1%. PDM manifests entirely in the dermis or subcutis and histopathologically mimics cutaneous melanoma metastasis due to its lack of connection to the overlying epidermis. A thorough history and examination, including imaging evaluation for metastatic disease, reveals no prior history or concurrent primary cutaneous or metastatic melanoma lesion. Despite its histopathologic similarities to melanoma metastasis, PDM is associated with an unexpectedly favorable prognosis. This review discusses the clinical and histopathologic features of PDM as a distinct subtype of melanoma, as well as the current approach to clinical staging and management.
原发性皮肤黑色素瘤（PDM）是黑色素瘤的一种罕见亚型，估计发病率<1%。PDM完全表现在真皮或皮下组织中，由于其与上方表皮缺乏连接，在组织病理学上类似于皮肤黑色素瘤转移。详细的病史和检查，包括对转移性疾病的影像学评估，均未发现既往病史或同时存在的原发性皮肤或转移性黑色素瘤病变。尽管PDM在组织病理学上与黑色素瘤转移相似，但其预后却出人意料地良好。本综述讨论了PDM作为黑色素瘤一种独特亚型的临床和组织病理学特征，以及目前的临床分期和管理方法。
