State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.
Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou, Jiangsu 215004, China.
J Control Release. 2024 Nov;375:249-268. doi: 10.1016/j.jconrel.2024.09.008. Epub 2024 Sep 12.
Cancer immunotherapy, as an emerging cancer treatment approach, harnesses the patient's own immune system to effectively prevent tumor recurrence or metastasis. However, its clinical application has been significantly hindered by relatively low immune response rates. In recent years, metal-based biomaterials have been extensively studied as effective immunomodulators and potential tools for enhancing anti-tumor immune responses, enabling the reversal of immune suppression without inducing toxic side effects. This review introduces the classification of bioactive metal elements and summarizes their immune regulatory mechanisms. In addition, we discuss the immunomodulatory roles of biomaterials constructed from various metals, including aluminum, manganese, gold, calcium, zinc, iron, magnesium, and copper. More importantly, a systematic overview of their applications in enhancing immunotherapy is provided. Finally, the prospects and challenges of metal-based biomaterials with immunomodulatory functions in cancer immunotherapy are outlined.
癌症免疫疗法作为一种新兴的癌症治疗方法，利用患者自身的免疫系统来有效预防肿瘤复发或转移。然而，其临床应用受到免疫反应率相对较低的显著阻碍。近年来，基于金属的生物材料已被广泛研究作为有效的免疫调节剂和增强抗肿瘤免疫反应的潜在工具，能够在不引起毒性副作用的情况下逆转免疫抑制。本综述介绍了生物活性金属元素的分类，并总结了它们的免疫调节机制。此外，我们讨论了由各种金属构建的生物材料的免疫调节作用，包括铝、锰、金、钙、锌、铁、镁和铜。更重要的是，系统地概述了它们在增强免疫治疗中的应用。最后，概述了具有免疫调节功能的基于金属的生物材料在癌症免疫治疗中的前景和挑战。
