Huang Zeng-Jin, Zhou Xin-Hui, Wen Wei-Qiu, Huang Ze-Ting, Xuan Jie, Gui Ping, Peng Weihua, Wang Guanhai
The First Dongguan Affiliated Hospital, Guangdong Medical University, 523710 Dongguan, China.
Huangpu Institute of Materials, Guangzhou, China.
Int J Pharm. 2024 Nov 15;665:124690. doi: 10.1016/j.ijpharm.2024.124690. Epub 2024 Sep 12.
Epigallocatechin-3-gallate (EGCG), a catechin present in green tea, has been studied extensively for its potential as a cosmetic ingredient due to its various biological properties. However, the low stability and bioavailability of EGCG have hindered its effective utilization in cosmetic applications. This study, to improve the stability and bioavailability of EGCG for reversing skin photo-aging, nonapeptide-1-conjugated mesoporous silica nanoparticles (EGCG@NP-MSN) were fabricated to load EGCG. MSNs can regulate the EGCG release and provide ultraviolet light (UV) protection to possess excellent photostability. Nonapeptide-1 exhibits melanin transfer interference properties and reduces the melanin content in treated skin areas. In vitro and in vivo results confirmed that the EGCG-loaded MSNs retained antioxidant properties, effectively scavenged the melanin and significantly reduced the deoxyribonucleic acid (DNA) damage in skin cells exposed to UV irradiation. The melanin inhibition rate is 5.22 times and the tyrosinase inhibition rate is 1.57 times that of free EGCG. The utilization of this innovative platform offers the potential for enhanced stability, controlled release, and targeted action of EGCG, thereby providing significant advantages for skin application.This delivery system combines the advantages of antioxidant, anti-aging, and anti-UV radiation properties, paving the way for the cosmetics development with improved efficacy and better performance in promoting skin health and appearance.
表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶中的一种儿茶素，因其多种生物学特性，作为一种化妆品成分的潜力已得到广泛研究。然而，EGCG的低稳定性和生物利用度阻碍了其在化妆品应用中的有效利用。本研究为提高EGCG的稳定性和生物利用度以逆转皮肤光老化，制备了负载EGCG的九肽-1共轭介孔二氧化硅纳米颗粒（EGCG@NP-MSN）。介孔二氧化硅纳米颗粒（MSNs）可以调节EGCG的释放，并提供紫外线（UV）防护，具有出色的光稳定性。九肽-1具有黑色素转移干扰特性，可降低处理皮肤区域的黑色素含量。体外和体内实验结果证实，负载EGCG的MSNs保留了抗氧化性能，有效清除了黑色素，并显著降低了暴露于紫外线照射的皮肤细胞中的脱氧核糖核酸（DNA）损伤。黑色素抑制率是游离EGCG的5.22倍，酪氨酸酶抑制率是游离EGCG的1.57倍。这种创新平台的应用为提高EGCG的稳定性、控制释放和靶向作用提供了潜力，从而为皮肤应用带来显著优势。这种递送系统结合了抗氧化、抗衰老和抗紫外线辐射特性的优点，为开发具有更高功效和更好性能的化妆品铺平了道路，以促进皮肤健康和改善外观。
