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入院后两天内进行手术可降低股骨转子间骨折患者的并发症和死亡率:一项日本诊断程序组合(DPC)研究

Surgery within Two Days of Admission Reduces Complications and Mortality of Patients with Trochanteric Femur Fractures: A Japanese DPC Study.

作者信息

Tanaka Hidetatsu, Tarasawa Kunio, Mori Yu, Fushimi Kiyohide, Fujimori Kenji, Aizawa Toshimi

机构信息

Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine.

Department of Health Administration and Policy, Tohoku University Graduate School of Medicine.

出版信息

Tohoku J Exp Med. 2025 Apr 18;265(4):211-219. doi: 10.1620/tjem.2024.J093. Epub 2024 Sep 12.

Abstract

An early surgery for older adult patients with hip fractures is recommended to avoid perioperative complications in existing clinical guidelines. Few studies have analyzed only transtrochanteric fractures. The purpose of this study was to assess whether surgery within two days of admission reduces the incidence of pneumonia, deep vein thrombosis, pulmonary embolism, pressure ulcers, and mortality during hospitalization in patients with older adult transtrochanteric femur fractures. In this retrospective study, we used the Japanese National Administrative DPC (Diagnosis Procedure Combination) database that covers April 2016 to March 2022. Transtrochanteric femur fracture was included in patients aged 65 years or older who underwent surgery. The perioperative complications with pneumonia, deep vein thrombosis, pulmonary embolism, pressure ulcers, and mortality during hospitalization were assessed after propensity score matching, focusing on surgeries conducted within two days of admission. After one-to-one propensity score matching for age, sex, and comorbidity, we identified 79,649 pairs of patients who underwent surgery either within two days or after the third day of admission. Surgery delayed beyond two days was independently associated with increased pneumonia, pulmonary embolism, pressure ulcers, and mortality during hospitalization with risk ratios of 1.335 (95% CI: 1.256-1.418, p < 0.0001), 1.287 (95% CI: 1.225-1.351, p < 0.0001), 1.229 (95% CI: 1.094-1.380, p < 0.0001), and 1.063 (95% CI: 0.978-1.155, p = 0.0035), respectively. Surgery within two days of admission for transtrochanteric femur fracture effectively prevents perioperative complications and reduces mortality during hospitalization.

摘要

现有临床指南建议,老年髋部骨折患者应尽早进行手术,以避免围手术期并发症。很少有研究仅分析转子间骨折。本研究的目的是评估入院两天内进行手术是否能降低老年股骨转子间骨折患者住院期间肺炎、深静脉血栓形成、肺栓塞、压疮和死亡率的发生率。在这项回顾性研究中,我们使用了覆盖2016年4月至2022年3月的日本国家行政DPC(诊断程序组合)数据库。纳入65岁及以上接受手术的股骨转子间骨折患者。在倾向得分匹配后,评估住院期间肺炎、深静脉血栓形成、肺栓塞、压疮和死亡率等围手术期并发症,重点关注入院两天内进行的手术。在对年龄、性别和合并症进行一对一倾向得分匹配后,我们确定了79649对分别在入院两天内或第三天后接受手术的患者。入院两天后延迟手术与住院期间肺炎、肺栓塞、压疮和死亡率增加独立相关,风险比分别为1.335(95%CI:1.256-1.418,p<0.0001)、1.287(95%CI:1.225-1.351,p<0.0001)、1.229(95%CI:1.094-1.380,p<0.0001)和1.063(95%CI:0.978-1.155,p=0.0035)。股骨转子间骨折入院两天内进行手术可有效预防围手术期并发症并降低住院期间的死亡率。

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