Central Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China.
Department of Urology, Shanghai Xuhui Central Hospital, Shanghai, China.
J Cell Mol Med. 2024 Sep;28(17):e70089. doi: 10.1111/jcmm.70089.
To investigate the causality between B cell count and psoriasis by Mendelian randomization (MR). Collected B cell count and psoriasis data from IEU Open GWAS Project. Employed inverse variance weighting (IVW), MR-Egger, WM, weighted mode for analysis, ensuring result robustness. Assessed horizontal pleiotropy with MR-Egger, detected outliers using MR-PRESSO and examined instrumental variables heterogeneity with Cochran's Q-test. The IVW method suggested an association between a genetically predicted memory B cell count and the risk of psoriasis vulgaris. IVW results also showed no causality between other exposure factors and the corresponding outcomes. Also, the global test of MR-PRESSO analysis showed a significant association between a genetically predicted transitional absolute B cell count and the lower risk of psoriasis vulgaris. MR-Egger regression showed that horizontal pleiotropy did not influence the analysis results. We found that memory B cell absolute counts are associated with a lower risk of psoriasis. These data further elucidate the role of memory B cells in psoriasis and provide new options for psoriasis treatment.
采用孟德尔随机化（MR）方法研究 B 细胞计数与银屑病之间的因果关系。从 IEU Open GWAS 项目中收集 B 细胞计数和银屑病数据。采用逆方差加权（IVW）、MR-Egger、WM 和加权模式进行分析，以确保结果的稳健性。采用 MR-Egger 评估水平多效性，使用 MR-PRESSO 检测异常值，并使用 Cochran's Q 检验检查工具变量异质性。IVW 方法表明，遗传预测的记忆 B 细胞计数与寻常型银屑病的风险之间存在关联。IVW 结果还表明，其他暴露因素与相应结局之间不存在因果关系。此外，MR-PRESSO 分析的全局检验显示，遗传预测的过渡性绝对 B 细胞计数与寻常型银屑病的较低风险之间存在显著关联。MR-Egger 回归表明，水平多效性并未影响分析结果。我们发现，记忆 B 细胞绝对计数与银屑病的较低风险相关。这些数据进一步阐明了记忆 B 细胞在银屑病中的作用，并为银屑病的治疗提供了新的选择。
