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经皮冠状动脉介入治疗后行非心脏手术患者中低分子肝素桥接与抗血小板治疗的比较:一项全面综述。

Bridging With Low-Molecular-Weight Heparin Versus Antiplatelet Therapy in Patients Undergoing Noncardiac Surgery After Percutaneous Coronary Intervention: A Comprehensive Review.

机构信息

Department of Cardiovascular Research, Cardiovascular Analytics Group, Islamabad, Pakistan.

Department of Interventional Cardiology, Ascension Borgess Hospital, Michigan, USA.

出版信息

Clin Cardiol. 2024 Sep;47(9):e70008. doi: 10.1002/clc.70008.

Abstract

BACKGROUND

This review article discussed the use of bridging therapy with low-molecular-weight heparin (LMWH) in patients who undergo noncardiac surgery (NCS) after percutaneous coronary intervention (PCI).

HYPOTHESES

Patients who undergo PCI are at an increased risk of thrombotic events due to their underlying cardiovascular disease. However, many of these patients may require NCS at some point in their lives, which poses a significant challenge for clinicians as they balance the risk of thrombotic events against the risk of bleeding associated with antithrombotic therapy.

RESULTS

This review evaluates the current evidence on the use of bridging therapy with LMWH in patients undergoing NCS after PCI, focusing on outcomes related to the efficacy and safety of antithrombotic therapy. The article also discusses the limitations of the current evidence and highlights areas where further research is needed to optimize the management of antithrombotic therapy in this patient population.

CONCLUSION

The goal of this review was to provide clinicians with a comprehensive summary of the available evidence to guide clinical decision-making and improve patient outcomes.

摘要

背景

本文综述了经皮冠状动脉介入治疗(PCI)后行非心脏手术(NCS)的患者中应用低分子肝素(LMWH)桥接治疗的情况。

假设

由于基础心血管疾病,行 PCI 的患者发生血栓事件的风险增加。然而,这些患者中的许多人在其一生中可能需要接受 NCS,这对临床医生来说是一个重大挑战,因为他们需要权衡血栓事件的风险与抗血栓治疗相关出血的风险。

结果

本综述评估了 PCI 后行 NCS 患者中应用 LMWH 桥接治疗的现有证据,重点关注与抗血栓治疗疗效和安全性相关的结局。本文还讨论了现有证据的局限性,并强调了需要进一步研究的领域,以优化该患者人群的抗血栓治疗管理。

结论

本综述的目的是为临床医生提供对现有证据的全面总结,以指导临床决策并改善患者结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5031/11390793/f81ab8fc2def/CLC-47-e70008-g001.jpg

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