Department of Anesthesiology, Baoding No.1 Central Hospital, Baoding, Hebei, 071000, China.
Department of Anesthesiology, Baoding Second Hospital, Baoding, Hebei, 071000, China.
Cell Mol Biol (Noisy-le-grand). 2024 Sep 8;70(8):148-152. doi: 10.14715/cmb/2024.70.8.20.
Cerebrovascular disease, one of the high-risk diseases worldwide, is high in morbidity, disability, mortality, and recurrence rates, which brings many harms to human beings such as physical and mental harm, economic losses, and impairment of social relations. Cerebral ischemia-reperfusion injury (CIRI) is one of the most common pathological manifestations, with mild hypothermia therapy being the most commonly used treatment in clinical practice. In this study, the research team established a CIRI animal model and found that the neuronal apoptosis rate was significantly increased, accompanied by significant ferroptosis, increased inflammation and oxidative stress damage in brain tissue, and obviously inhibited SIRT1/AMPK pathway. However, after mild hypothermia treatment, the pathological changes of CIRI rats were significantly reversed, and the SIRT1/AMPK pathway was reactivated. Therefore, mild hypothermia may achieve the purpose of CIRI repair by activating the SIRT1/AMPK signaling pathway, and targeted regulation of the SIRT1/AMPK signaling pathway may be a research direction for optimizing mild hypothermia therapy or developing new treatment plans for CIRI.
脑血管疾病是全球高发疾病之一，具有发病率、致残率、致死率和复发率高的特点，给人类带来身心伤害、经济损失和社会关系受损等诸多危害。脑缺血再灌注损伤（CIRI）是最常见的病理表现之一，临床实践中最常用的治疗方法是轻度低温治疗。在本研究中，研究团队建立了 CIRI 动物模型，发现神经元细胞凋亡率显著增加，同时伴有明显的铁死亡、脑组织炎症和氧化应激损伤，明显抑制 SIRT1/AMPK 通路。然而，经过轻度低温治疗后，CIRI 大鼠的病理变化明显逆转，SIRT1/AMPK 通路被重新激活。因此，轻度低温可能通过激活 SIRT1/AMPK 信号通路来达到修复 CIRI 的目的，靶向调节 SIRT1/AMPK 信号通路可能是优化轻度低温治疗或开发 CIRI 新治疗方案的研究方向。
