Liggins G C
Prostaglandins. 1979 Jul;18(1):167-72. doi: 10.1016/s0090-6980(79)80035-0.
A group of 84 women at 39-43 weeks of pregnancy were randomly allocated to a blind trial of induction of labor with vaginal suppositories containing inert material or either 0.2 mg or 0.4 mg of prostaglandin E2. The suppositories were self-administered every two hours during waking hours on two successive days until labor started or 15 had been used. Side-effects were absent. Labor was established within 48 hr of insertion of the first suppository in 9.3% of control patients, 65.4% of those treated with 0.2 mg PGE2 and 85.7% of those treated with 0.4 mg PGE2. The mean Apgar scores in the three groups were the same. The mean total dose of PGE2 were 2.0 mg (0.2 mg group) and 2.3 mg (0.4 mg group). It is concluded that vaginal PGE2 is an effective and acceptable method of inducing labor at term.
一组84名怀孕39至43周的女性被随机分配到一项盲法试验中，使用含有惰性物质或0.2毫克或0.4毫克前列腺素E2的阴道栓剂引产。在连续两天的清醒时间里，每两小时自行使用一次栓剂，直到分娩开始或使用了15枚为止。未出现副作用。在对照组患者中，9.3%在插入第一枚栓剂后48小时内分娩，使用0.2毫克前列腺素E2治疗的患者中这一比例为65.4%，使用0.4毫克前列腺素E2治疗的患者中这一比例为85.7%。三组的平均阿普加评分相同。前列腺素E2的平均总剂量在0.2毫克组为2.0毫克，在0.4毫克组为2.3毫克。结论是，阴道使用前列腺素E2是足月引产的一种有效且可接受的方法。
