Romero Kaitlyn N, O'Brien Melville C, Agrawal Avni, Hasan Irtiza
Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Cureus. 2024 Aug 12;16(8):e66715. doi: 10.7759/cureus.66715. eCollection 2024 Aug.
Rhabdomyolysis is the breakdown of muscle cells secondary to both traumatic and non-traumatic causes. The lysing of the muscle cells can lead to the release of cell contents that can lead to acute injury and other life-threatening conditions. Levetiracetam is an anticonvulsant commonly used in generalized and partial tonic-clonic seizures. Well-known side effects include agitation, depression, anxiety, irritability, rash, and somnolence; however, there are an increasing number of case reports that report rhabdomyolysis secondary to antiepileptic use. We present a case of a 27-year-old male with new-onset seizures who was started on levetiracetam therapy and found to have elevated creatine kinase (CK), which decreased only with tapering of the drug. Our case displays the importance of considering levetiracetam as a cause of rhabdomyolysis, supporting this rare side effect of the antiseizure medication. Rhabdomyolysis is a potentially life-threatening condition that can lead to irreversible renal damage if not managed properly.
横纹肌溶解症是继发于创伤性和非创伤性原因的肌肉细胞分解。肌肉细胞的溶解可导致细胞内容物释放，进而引发急性损伤和其他危及生命的状况。左乙拉西坦是一种常用于全身性和部分性强直阵挛性癫痫发作的抗惊厥药物。其众所周知的副作用包括激动、抑郁、焦虑、易怒、皮疹和嗜睡；然而，越来越多的病例报告称抗癫痫药物使用后会继发横纹肌溶解症。我们报告一例27岁新发癫痫男性患者，开始接受左乙拉西坦治疗后发现肌酸激酶（CK）升高，仅在药物减量时才下降。我们的病例显示了将左乙拉西坦视为横纹肌溶解症病因的重要性，支持了这种抗癫痫药物罕见的副作用。横纹肌溶解症是一种潜在的危及生命的状况，如果处理不当可导致不可逆的肾损伤。
