Liu Boyu, Wei Ran, Zhu Hongbo, Zhao Xuelu, Wang Guang
Department of Orthopedics, Affiliated Hospital of Hebei Engineering University Handan 056000, Hebei, China.
Department of Orthopedics, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Cangzhou 056000, Hebei, China.
Am J Transl Res. 2024 Aug 15;16(8):3851-3858. doi: 10.62347/NEOQ3253. eCollection 2024.
The combinative effects of neuromuscular electrical stimulation and ibuprofen on pain in patients with femoral head necrosis were discussed and analyzed.
This retrospective study analyzed data of 60 patients with femoral head necrosis hospitalized during Oct. 2020 to Oct. 2021. According to different treatment methods, the patients were divided into an observation group and a control group (30 cases in each group). The control group took oral ibuprofen sustained-release capsules, and the observation group was treated with neuromuscular electrical stimulation in addition to ibuprofen. Both groups received a 4-week treatment course. The therapeutic efficacy, Harris scale scores, Visual Analogue Scale (VAS) score, MRI hip imaging stage, SF-36 scale score, serum plasminogen activator inhibitor 1 (PAI-1), leptin and osteopontin levels before and after treatment were compared between the two groups.
After treatment, the overall response rate in the observation group was higher than that in control group (). The post-treatment scores of Harris scale were higher in both groups than those pre-treatment (), and were higher in the observation group than in the control group (). The VAS scores were decreased in both groups (), and the decrease was more significant in the observation group than in the control group (). After treatment, there were more patients with 0-I MRI hip imaging stage in the two groups than before treatment (), and more in the observation group than in the control group (). The SF-36 scores in both groups were increased (), and the increase was more significant in the observation group than in the control group (). The serum levels of PAI-1, leptin and osteopontin were decreased in both groups (), and the decreases were more significant in the observation group than in the control group ().
The combinative treatment of neuromuscular electrical stimulation and ibuprofen has a significant effect on patients with femoral head necrosis. The treatment can remarkably reduce patients' pain, improve their hip function and quality of life, and decrease the PAI-1, leptin and osteopontin levels.
探讨并分析神经肌肉电刺激与布洛芬联合应用对股骨头坏死患者疼痛的影响。
本回顾性研究分析了2020年10月至2021年10月期间住院的60例股骨头坏死患者的数据。根据不同治疗方法，将患者分为观察组和对照组（每组30例）。对照组口服布洛芬缓释胶囊，观察组在布洛芬基础上接受神经肌肉电刺激治疗。两组均接受为期4周的治疗疗程。比较两组治疗前后的治疗效果、Harris评分、视觉模拟评分（VAS）、髋关节MRI成像分期、SF-36评分、血清纤溶酶原激活物抑制剂1（PAI-1）、瘦素和骨桥蛋白水平。
治疗后，观察组的总有效率高于对照组（）。两组治疗后的Harris评分均高于治疗前（），且观察组高于对照组（）。两组VAS评分均降低（），且观察组降低更显著（）。治疗后，两组髋关节MRI成像0-I期患者均多于治疗前（），且观察组多于对照组（）。两组SF-36评分均升高（），且观察组升高更显著（）。两组血清PAI-1、瘦素和骨桥蛋白水平均降低（），且观察组降低更显著（）。
神经肌肉电刺激与布洛芬联合治疗对股骨头坏死患者有显著效果。该治疗可显著减轻患者疼痛，改善髋关节功能和生活质量，并降低PAI-1、瘦素和骨桥蛋白水平。
