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虫草素对登革病毒感染具有抗病毒和抗炎作用。

Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection.

作者信息

Songprakhon Pucharee, Panya Aussara, Choomee Kornkan, Limjindaporn Thawornchai, Noisakran Sansanee, Tarasuk Mayuri, Yenchitsomanus Pa-Thai

机构信息

Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Natural Extracts and Innovative Products for Alternative Healthcare Research Group, Chiang Mai University, Chiang Mai 50200, Thailand.

出版信息

iScience. 2024 Aug 13;27(9):110711. doi: 10.1016/j.isci.2024.110711. eCollection 2024 Sep 20.

DOI:10.1016/j.isci.2024.110711
PMID:39262808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11387592/
Abstract

Cordycepin, a natural derivative of adenosine from , can inhibit the replication of the dengue virus (DENV). Here, we investigated its antiviral and anti-inflammatory effects in DENV infected cells. Cordycepin significantly inhibited DENV-2 infection, virion production, and viral protein synthesis. It also reduced DENV-induced cytokine/chemokine production, including RANTES, IP-10, IL-6, and TNF-α. Mechanistically, cordycepin targeted the DENV NS5 protein, suppressing RANTES expression and hindering viral replication. Additionally, it inhibited the NF-κB pathway, leading to reduced nuclear translocation and signaling deactivation. PCR array analysis revealed cordycepin's suppression of 46 genes associated with DENV-induced inflammation. These findings highlight cordycepin's dual potential as an antiviral and anti-inflammatory agent against DENV, making it as a promising candidate for dengue treatment, targeting both viral and host factors.

摘要

虫草素是腺苷的一种天然衍生物，能够抑制登革病毒（DENV）的复制。在此，我们研究了其在DENV感染细胞中的抗病毒和抗炎作用。虫草素显著抑制DENV-2感染、病毒粒子产生和病毒蛋白合成。它还减少了DENV诱导的细胞因子/趋化因子产生，包括调节激活正常T细胞表达和分泌的趋化因子（RANTES）、干扰素诱导蛋白10（IP-10）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。从机制上讲，虫草素靶向DENV NS5蛋白，抑制RANTES表达并阻碍病毒复制。此外，它抑制核因子κB（NF-κB）途径，导致核转位减少和信号失活。聚合酶链反应（PCR）芯片分析显示虫草素抑制了46个与DENV诱导的炎症相关的基因。这些发现突出了虫草素作为一种针对DENV的抗病毒和抗炎药物的双重潜力，使其成为一种有前途的登革热治疗候选药物，可同时针对病毒和宿主因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/2f6bea2dc95c/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/9bad010db741/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/8b80162d40d1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/a253d5816ec4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/a695626220ab/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/b6d23b42f087/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/e06c70cb1f4b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/d4ae4bf53e8c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/2b776120956f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/54f91518f8bd/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/4e3c9444807d/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/2f6bea2dc95c/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/9bad010db741/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/8b80162d40d1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/a253d5816ec4/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/a695626220ab/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/b6d23b42f087/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/e06c70cb1f4b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/d4ae4bf53e8c/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/2b776120956f/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/54f91518f8bd/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/4e3c9444807d/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e3a/11387592/2f6bea2dc95c/gr10.jpg

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