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REGN5093-M114: can an antibody-drug conjugate overcome the challenge of resistance to epidermal growth factor receptor and mesenchymal epithelial transition tyrosine kinase inhibitors in non-small cell lung cancer?

作者信息

Dardare Julie, Witz Andréa, Harlé Alexandre

机构信息

Service de Biopathologie, Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy, France.

Université de Lorraine, Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 7039 Centre de Recherche en Automatique de Nancy (CRAN), Nancy, France.

出版信息

Transl Lung Cancer Res. 2024 Aug 31;13(8):2082-2086. doi: 10.21037/tlcr-24-144. Epub 2024 Jul 26.

DOI:10.21037/tlcr-24-144
PMID:39263036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11384497/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4e/11384497/6b894b9cba0d/tlcr-13-08-2082-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4e/11384497/6b894b9cba0d/tlcr-13-08-2082-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a4e/11384497/6b894b9cba0d/tlcr-13-08-2082-f1.jpg

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Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis.Tepotinib 联合吉非替尼对比化疗用于因 MET 扩增导致 EGFR 抑制剂耐药的 EGFR 突变 NSCLC 的随机试验:INSIGHT 最终分析。
Clin Cancer Res. 2023 May 15;29(10):1879-1886. doi: 10.1158/1078-0432.CCR-22-3318.
2
Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial.AURA3 试验中 EGFR 突变型晚期非小细胞肺癌患者奥希替尼获得性耐药机制分析。
Nat Commun. 2023 Feb 27;14(1):1071. doi: 10.1038/s41467-023-35962-x.
3
MET alterations in NSCLC-Current Perspectives and Future Challenges.
非小细胞肺癌中的 MET 改变:现状与未来挑战。
J Thorac Oncol. 2023 Apr;18(4):419-435. doi: 10.1016/j.jtho.2022.10.015. Epub 2022 Oct 29.
4
Phase Ib Study of Telisotuzumab Vedotin in Combination With Erlotinib in Patients With c-Met Protein-Expressing Non-Small-Cell Lung Cancer.Telisotuzumab Vedotin 联合厄洛替尼治疗 c-Met 蛋白表达的非小细胞肺癌的 Ib 期研究。
J Clin Oncol. 2023 Feb 10;41(5):1105-1115. doi: 10.1200/JCO.22.00739. Epub 2022 Oct 26.
5
Preclinical Study of a Biparatopic METxMET Antibody-Drug Conjugate, REGN5093-M114, Overcomes MET-driven Acquired Resistance to EGFR TKIs in EGFR-mutant NSCLC.一种双靶点 METxMET 抗体药物偶联物,REGN5093-M114 的临床前研究,克服了 EGFR 突变 NSCLC 中 MET 驱动的获得性对 EGFR TKI 的耐药性。
Clin Cancer Res. 2023 Jan 4;29(1):221-232. doi: 10.1158/1078-0432.CCR-22-2180.
6
Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study.阿美替尼治疗 EGFR 外显子 20 插入突变型非小细胞肺癌:CHRYSALIS Ⅰ期研究的初步结果。
J Clin Oncol. 2021 Oct 20;39(30):3391-3402. doi: 10.1200/JCO.21.00662. Epub 2021 Aug 2.
7
A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade.一种双靶向抗体药物偶联物,用于治疗 MET 表达的癌症,包括那些对 MET 通路阻断无反应的癌症。
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Clin Cancer Res. 2020 Mar 15;26(6):1408-1419. doi: 10.1158/1078-0432.CCR-19-2428. Epub 2019 Dec 17.