Murphy Fionnuala C, Peers Polly V, Das Tilak, Manly Tom
Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Department of Radiology, Cambridge University Hospitals NHS Trust, Cambridge, UK.
Neuropsychol Rehabil. 2025 Jul;35(6):1160-1184. doi: 10.1080/09602011.2024.2393374. Epub 2024 Sep 12.
Acquired Brain Injury (ABI), an important cause of long-term disability, is associated with increased rates of depression in addition to common cognitive and physical consequences. Past research has linked post-ABI depression to injury severity (e.g., extent of physical or cognitive impairment) and premorbid mood problems. In the general (non-ABI) population, depression is associated with cognitive vulnerabilities that have informed the development of psychological interventions. In this observational study in a heterogeneous sample of individuals with chronic stage ABI, we examine two cognitive vulnerabilities - dysfunctional attitudes (DAs) and autobiographical memory specificity - and explore whether these are linked to depression symptoms and ongoing cognitive difficulties as in the general population. Compared to control participants, individuals with an ABI demonstrated increased endorsement of DAs and reduced specificity of autobiographical memory recall. Within the ABI group, cognitive vulnerability-depression symptom correlations were detected for an explicit measure of DAs, but not for a more implicit DA measure or for autobiographical memory specificity. While individual differences in injury severity and other factors likely obscured subtle relationships between mood and cognitive vulnerabilities, evidence of these vulnerabilities may be relevant to changes in identity and psychological interventions that target low mood in ABI.
获得性脑损伤(ABI)是导致长期残疾的一个重要原因,除了常见的认知和身体后果外,还与抑郁症发病率增加有关。过去的研究已将ABI后的抑郁症与损伤严重程度(如身体或认知障碍的程度)以及病前情绪问题联系起来。在一般(非ABI)人群中,抑郁症与认知易损性有关,这些认知易损性为心理干预的发展提供了依据。在这项针对慢性期ABI个体的异质性样本的观察性研究中,我们考察了两种认知易损性——功能失调性态度(DAs)和自传体记忆特异性,并探讨它们是否像在一般人群中那样与抑郁症状和持续的认知困难有关。与对照组参与者相比,ABI个体表现出对DAs的认同增加,自传体记忆回忆的特异性降低。在ABI组中,对于DAs的一项显性测量检测到了认知易损性与抑郁症状的相关性,但对于一项更隐性的DAs测量或自传体记忆特异性则未检测到。虽然损伤严重程度和其他因素的个体差异可能掩盖了情绪与认知易损性之间的微妙关系,但这些易损性的证据可能与身份变化以及针对ABI患者情绪低落的心理干预有关。