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Cancer Diagn Progn. 2024 Mar 3;4(2):172-181. doi: 10.21873/cdp.10304. eCollection 2024 Mar-Apr.
2
Long Non-Coding RNA Signatures in Lymphopoiesis and Lymphoid Malignancies.淋巴细胞生成和淋巴样恶性肿瘤中的长链非编码RNA特征
Noncoding RNA. 2023 Aug 1;9(4):44. doi: 10.3390/ncrna9040044.
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Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty.对人类外周血的多维度单细胞分析揭示了衰老和虚弱状态下免疫系统格局的特征。
Nat Aging. 2022 Apr;2(4):348-364. doi: 10.1038/s43587-022-00198-9. Epub 2022 Apr 18.
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Antisense lncRNA is linked to glioma patient survival.反义长链非编码RNA与胶质瘤患者的生存率相关。
Front Mol Biosci. 2023 Mar 6;10:1101953. doi: 10.3389/fmolb.2023.1101953. eCollection 2023.
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Long non-coding RNAs: definitions, functions, challenges and recommendations.长非编码 RNA：定义、功能、挑战与建议。
Nat Rev Mol Cell Biol. 2023 Jun;24(6):430-447. doi: 10.1038/s41580-022-00566-8. Epub 2023 Jan 3.
6
Effect of miR-27b on the proliferation and apoptosis of diffuse large b-cell lymphoma cells by targeting the regulation of MET/PI3K/AKT pathway.miR-27b通过靶向调控MET/PI3K/AKT通路对弥漫性大B细胞淋巴瘤细胞增殖和凋亡的影响
Discov Oncol. 2022 Dec 11;13(1):137. doi: 10.1007/s12672-022-00589-9.
7
NEAT1 promotes the malignant development of bladder cancer by regulating the miR-101/VEGF-C pathway in vitro and in vivo.NEAT1 通过调控 miR-101/VEGF-C 通路促进膀胱癌的体外和体内恶性发展。
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8
An overview of long noncoding RNAs: Biology, functions, therapeutics, analysis methods, and bioinformatics tools.长链非编码RNA综述：生物学、功能、治疗学、分析方法及生物信息学工具
Cell Biochem Funct. 2022 Dec;40(8):800-825. doi: 10.1002/cbf.3748. Epub 2022 Sep 16.
9
Long noncoding RNA regulates antiviral immunity in humans.长非编码 RNA 调控人类抗病毒免疫。
Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2210321119. doi: 10.1073/pnas.2210321119. Epub 2022 Aug 24.
10
A 9-LncRNA Signature for Predicting Prognosis and Immune Response in Diffuse Large B-Cell Lymphoma.一个 9-LncRNA 标志物，用于预测弥漫性大 B 细胞淋巴瘤的预后和免疫反应。
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NEAT1 和 CHROMR lncRNAs：弥漫性大 B 细胞淋巴瘤的一种有前途的诊断工具，尤其是在老年患者中。

NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients.

机构信息

Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, 5166/15731, Iran.

Dr. Saber Medical Genetics Laboratory, Almas Complex, Namaz Blvd., Golsar, Rasht, Gilan, 4165685538, Iran.

出版信息

Biomark Med. 2024 Aug 17;18(15-16):685-693. doi: 10.1080/17520363.2024.2389036. Epub 2024 Sep 12.

DOI:10.1080/17520363.2024.2389036
PMID:39263799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11404575/
Abstract

Long non-coding (lnc) RNAs have crucial regulatory roles in molecular pathways, and their dysregulation is associated with the pathogenesis of malignancies such as Diffuse large B-cell lymphoma (DLBCL). Therefore, we aimed to study the NEAT1 and CHROMR expression in DLBCL and explore their association with clinicopathological characteristics. DLBCL and non-tumor lymph node specimens were obtained to assess the expression levels. NEAT1 and CHROMR expressions were significantly increased in DLBCL, and were linked with the age of DLBCL patients (aged >60). NEAT1 and CHROMR overexpression may serve as moderate-to-good diagnostic biomarkers, with NEAT1 and CHROMR exhibiting area under the curve values of 0.781 and 0.831, respectively.

摘要

长链非编码 (lnc) RNA 在分子途径中具有关键的调节作用，其失调与弥漫性大 B 细胞淋巴瘤 (DLBCL) 等恶性肿瘤的发病机制有关。因此，我们旨在研究 DLBCL 中 NEAT1 和 CHROMR 的表达，并探讨其与临床病理特征的关系。收集 DLBCL 和非肿瘤淋巴结标本以评估表达水平。结果显示，DLBCL 中 NEAT1 和 CHROMR 的表达明显增加，且与 DLBCL 患者的年龄（>60 岁）有关。NEAT1 和 CHROMR 的过表达可能是中等至良好的诊断生物标志物，其曲线下面积分别为 0.781 和 0.831。