NEAT1 和 CHROMR lncRNAs：弥漫性大 B 细胞淋巴瘤的一种有前途的诊断工具，尤其是在老年患者中。
NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients.
机构信息
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, 5166/15731, Iran.
Dr. Saber Medical Genetics Laboratory, Almas Complex, Namaz Blvd., Golsar, Rasht, Gilan, 4165685538, Iran.
出版信息
Biomark Med. 2024 Aug 17;18(15-16):685-693. doi: 10.1080/17520363.2024.2389036. Epub 2024 Sep 12.
Long non-coding (lnc) RNAs have crucial regulatory roles in molecular pathways, and their dysregulation is associated with the pathogenesis of malignancies such as Diffuse large B-cell lymphoma (DLBCL). Therefore, we aimed to study the NEAT1 and CHROMR expression in DLBCL and explore their association with clinicopathological characteristics. DLBCL and non-tumor lymph node specimens were obtained to assess the expression levels. NEAT1 and CHROMR expressions were significantly increased in DLBCL, and were linked with the age of DLBCL patients (aged >60). NEAT1 and CHROMR overexpression may serve as moderate-to-good diagnostic biomarkers, with NEAT1 and CHROMR exhibiting area under the curve values of 0.781 and 0.831, respectively.
长链非编码 (lnc) RNA 在分子途径中具有关键的调节作用，其失调与弥漫性大 B 细胞淋巴瘤 (DLBCL) 等恶性肿瘤的发病机制有关。因此，我们旨在研究 DLBCL 中 NEAT1 和 CHROMR 的表达，并探讨其与临床病理特征的关系。收集 DLBCL 和非肿瘤淋巴结标本以评估表达水平。结果显示，DLBCL 中 NEAT1 和 CHROMR 的表达明显增加，且与 DLBCL 患者的年龄（>60 岁）有关。NEAT1 和 CHROMR 的过表达可能是中等至良好的诊断生物标志物，其曲线下面积分别为 0.781 和 0.831。
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