Discovery of novel dihydro-pyrimidine hybrids: insight into the design, synthesis, biological evaluation and absorption, distribution, metabolism and excretion studies.

By keeping in aspects, the pharmacological potential of heterocyclic compounds, pyrimidine-based compounds were designed, synthesized and evaluated for α-amylase inhibitory potential. Five new series 1a-l, 2a-d, 3a-d, 4a-d and 5a-d of 1,2,3,4-tetrahydroprimidine-5-carboxylate derivatives were designed by method by taking Alogliptin as reference compound. Here in we describe synthesis and characterization of compounds as potential α-amylase inhibitor. Structure activity relationship (SAR), analysis and molecular modelling approaches generate compounds and as potential lead with good α-amylase inhibitory selection. However, compound failed the criteria of optimization as drug lead by ADME studies while all other compounds showed optimum range for all ADME parameters. Therefore, these compounds can serve as potential lead candidate in developing anti-diabetic therapy.