Menbari Oskouie Iman, Akhavizadegan Hamed, Kasaeian Amir, Esmaeilpanah Shima, Lotfi Mohammad
Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Urology Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Urologia. 2025 Feb;92(1):112-119. doi: 10.1177/03915603241278112. Epub 2024 Sep 12.
Infertility is a growing issue globally, particularly in industrialized cultures, affecting 13%-18% of couples of reproductive ages. In recent years, numerous studies have aimed to identify prognostic factors for infertility and abnormal semen analysis. To date, no study has examined the relationship between the number of infertile siblings and abnormal sperm parameters. This study aims to investigate whether the number of infertile siblings can be considered a prognostic factor for abnormal sperm parameters.
Semen samples were collected from the male partners of couples experiencing infertility issues. Study participants completed a questionnaire detailing demographic information including age and family history of infertility. Each participant provided two semen samples, with a minimum 15-day interval between collections. Sperm concentration, motility, and morphology were assessed for each sample. Clinical investigators conducted physical examinations, using an orchidometer to measure testicular size.
The number of infertile brothers and testis volume were prognostic factors for abnormal sperm count (OR = 1.374, -value = 0.03; OR = 0.786, -value < 0.001; respectively) and abnormal motility (OR = 1.514, -value = 0.018; OR = 26.74, -value < 0.001, respectively). There was no significant association between the percentage of abnormal morphology of sperm cells and the mentioned prognostic factors. The optimal cut-off point of the number of infertile brothers for both abnormal sperm count and abnormal sperm motility was one.
It is recommended that males with at least one infertile brother, undergo sperm analysis to identify individuals at risk of infertility.
不孕是一个在全球范围内日益严重的问题，尤其是在工业化文化中，影响着13%-18%的育龄夫妇。近年来，众多研究旨在确定不孕和精液分析异常的预后因素。迄今为止，尚无研究探讨不孕兄弟姐妹的数量与精子参数异常之间的关系。本研究旨在调查不孕兄弟姐妹的数量是否可被视为精子参数异常的预后因素。
从有不孕问题的夫妇中的男性伴侣收集精液样本。研究参与者完成一份详细列出人口统计学信息（包括年龄和不孕家族史）的问卷。每位参与者提供两份精液样本，采集间隔至少15天。对每个样本评估精子浓度、活力和形态。临床研究人员进行体格检查，使用睾丸测量器测量睾丸大小。
不孕兄弟的数量和睾丸体积分别是精子计数异常（OR = 1.374，P值 = 0.03；OR = 0.786，P值 < 0.001）和活力异常（OR = 1.514，P值 = 0.018；OR = 26.74，P值 < 0.001）的预后因素。精子细胞形态异常百分比与上述预后因素之间无显著关联。对于精子计数异常和精子活力异常，不孕兄弟数量的最佳切点均为1。
建议至少有一个不孕兄弟的男性进行精子分析，以识别有不孕风险的个体。
