Mendez Donna R, Paul Krishna, Richardson Joan, Jehle Dietrich
Department of Emergency Medicine, University of Texas Medical Branch, Galveston, TX.
Department of Pediatrics, University of Texas Medical Branch, Galveston, TX.
Pediatr Emerg Care. 2025 Mar 1;41(3):226-229. doi: 10.1097/PEC.0000000000003274. Epub 2024 Sep 12.
Our objective was to evaluate the risk of urinary tract infection (UTI) and bacteremia in infants 1 year or less of age infected with COVID-19.
This was a retrospective study from TriNetX database in the United States. This study was from March 11, 2020, to May 11, 2023, during the COVID-19 pandemic. Patients were included if they were infants, 1 year or less, had a fever, and had a COVID-19 polymerase chain reaction test 1 week before or after presentation to the emergency department (ED) or hospital. We compared outcomes of bacteremia and a UTI in those with COVID-19 and those without COVID-19. Propensity matching was done to account for the confounders of age, gender, race, immune disorders, genitourinary abnormalities, preterm birth, and circumcision.
Infants who were positive for COVID-19 were at a reduced risk of UTI and bacteremia. There was a significant decreased risk of having a UTI if one had COVID-19 (1.0%) versus those without COVID-19 (2.3%) (risk ratio = 0.37, 95% confidence interval = 0.37-0.50, P < 0.001). For bacteremia, there was also a decreased risk if the infant had COVID-19 (0.4%), versus those without COVID-19 (0.5%) (risk ratio = 0.74, 95% confidence interval = 0.56-0.97, P = 0.03).
Infants with fever found to have COVID-19 had lower risks of UTI and bacteremia.
我们的目的是评估1岁及以下感染新冠病毒（COVID-19）的婴儿发生尿路感染（UTI）和菌血症的风险。
这是一项来自美国TriNetX数据库的回顾性研究。该研究涵盖了2020年3月11日至2023年5月11日新冠疫情期间。纳入的患者为1岁及以下的婴儿，有发热症状，且在急诊科（ED）或医院就诊前或就诊后1周内进行了新冠病毒聚合酶链反应检测。我们比较了感染新冠病毒和未感染新冠病毒的患者发生菌血症和UTI的结果。采用倾向匹配法以考虑年龄、性别、种族、免疫紊乱、泌尿生殖系统异常、早产和包皮环切术等混杂因素。
新冠病毒检测呈阳性的婴儿发生UTI和菌血症的风险降低。感染新冠病毒的患者发生UTI的风险显著低于未感染新冠病毒的患者（1.0%对2.3%）（风险比 = 0.37，95%置信区间 = 0.37 - 0.50，P < 0.001）。对于菌血症，感染新冠病毒的婴儿风险也较低（0.4%），而未感染新冠病毒的婴儿为（0.5%）（风险比 = 0.74，95%置信区间 = 0.56 - 0.97，P = 0.03）。
发热且新冠病毒检测呈阳性的婴儿发生UTI和菌血症的风险较低。
