Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow, Russia.
Bull Exp Biol Med. 2024 Aug;177(4):460-464. doi: 10.1007/s10517-024-06208-7. Epub 2024 Sep 12.
We studied the anti-anxiety effect of a low-molecular-weight mimetic of the BDNF loop 2, hexamethylenediamide bis-(-N-hexanoyl-L-seryl-L-lysine) (GTS-201) in adult animals. GTS-201 at a dose of 5 mg/kg after acute intraperitoneal administration to outbred male and female rats increased the time spent in the open arms and the number of entries into the open arms in the elevated plus maze (EPM). In "highly emotional" male BALB/c mice, GTS-201 exhibited a dose-dependent anxiolytic effect in the EPM in a dose range of 0.5-2.0 mg/kg with a maximum effective dose of 1 mg/kg. These data confirm the previously revealed anti-anxiety properties of GTS-201 in inbred male and female BALB/c mice and rats and indicate the dependence of the pharmacological activity of the BDNF mimetic on animal age.
我们研究了一种 BDNF 环 2 的低分子量类似物六亚甲基二胺双（-N-己酰基-L-丝氨酰基-L-赖氨酸）（GTS-201）在成年动物中的抗焦虑作用。GTS-201 在急性腹腔内给药 5mg/kg 后，可增加广口迷宫（EPM）中开放臂的停留时间和进入开放臂的次数。在“高情感”的雄性 BALB/c 小鼠中，GTS-201 在 EPM 中表现出剂量依赖性的抗焦虑作用，剂量范围为 0.5-2.0mg/kg，最大有效剂量为 1mg/kg。这些数据证实了 GTS-201 在近交系雄性和雌性 BALB/c 小鼠和大鼠中的抗焦虑特性，并表明 BDNF 类似物的药理学活性依赖于动物年龄。
