Beijing University of Chinese Medicine, No. 11 Beisanhuan East Road, Heping Street, Chaoyang District, Beijing, 100029, China.
Department of Brain Disease III, Dongfang Hospital Beijing University of Chinese Medicine, No. 6, Fangxingyuan District 1, Fangzhuang, Fengtai District, Beijing, 100078, China.
Cereb Cortex. 2024 Sep 3;34(9). doi: 10.1093/cercor/bhae349.
Inflammation may be related to structural changes in the cerebral cortex. We aimed to explore whether cytokines mediate the link between these changes and primary headache. The summary statistics of genome-wide association study (GWAS) related to migraine and its subtypes, cluster headache were derived from the FinnGen Release 10 database, and tension-type headache data was from the GWAS Catalog. Ninety-one cytokines were obtained from genome-wide pQTL mapping data. GWAS data on cortical surface area (SA) and thickness (TH) came from the ENIGMA Consortium. The methods of Mendelian randomization (MR) analysis included the inverse-variance-weighted (IVW), MR-Egger, and weighted median. Migraine reduces the SA of paracentral[β = -1.3645, OR = 0.2555, 95%CI (0.0660, 0.9898)] by fibroblast growth factor-23(FGF-23), with an intermediate ratio (IR) of 38.13%. Migraine may reduce the TH of superior parietal[β = -0.0029, OR = 0.9971, 95%CI (0.9943, 0.9999)] by interleukin (IL)-15RA, with an absolute IR of 11.11%. Migraine without aura may reduce the TH of rostral anterior cingulate[β = -0.0005, OR = 0.9995, 95%CI (0.9991, 0.9999)] by IL-18R1, with an IR of 11.63%. FGF23 and IL-15RA are associated with reduced SA or TH in migraine, while IL-18R1 is associated with increased TH in migraine without aura.
炎症可能与大脑皮层的结构变化有关。我们旨在探讨细胞因子是否介导这些变化与原发性头痛之间的联系。偏头痛及其亚型、集群性头痛的全基因组关联研究（GWAS）汇总统计数据来自芬兰遗传（FinnGen）释放 10 数据库，紧张性头痛数据来自 GWAS 目录。从全基因组 pQTL 图谱数据中获得了 91 种细胞因子。皮质表面积（SA）和厚度（TH）的 GWAS 数据来自 ENIGMA 联盟。孟德尔随机化（MR）分析方法包括逆方差加权（IVW）、MR-Egger 和加权中位数。偏头痛通过成纤维细胞生长因子 23（FGF-23）降低旁中央区 SA[β=-1.3645，OR=0.2555，95%CI（0.0660，0.9898）]，中间比（IR）为 38.13%。偏头痛可能通过白细胞介素（IL）-15RA 降低上顶叶 TH[β=-0.0029，OR=0.9971，95%CI（0.9943，0.9999）]，绝对 IR 为 11.11%。无先兆偏头痛可能通过白细胞介素 18 受体 1（IL-18R1）降低额前扣带皮质 TH[β=-0.0005，OR=0.9995，95%CI（0.9991，0.9999）]，IR 为 11.63%。FGF23 和 IL-15RA 与偏头痛中的 SA 或 TH 降低有关，而 IL-18R1 与无先兆偏头痛中的 TH 增加有关。
