Stephan Jean-François, Karam Sani
Department of Family Medicine, McGill University, Montreal, Canada.
J Palliat Med. 2025 Apr;28(4):557-559. doi: 10.1089/jpm.2024.0277. Epub 2024 Sep 12.
Psilocybin-assisted therapy (PAT) has gained traction in palliative care as a treatment for existential distress in the last decade. Patients with brain cancer have been excluded from studies, yet they stand to benefit as much as other patients with cancer-related psychological distress. In this report, we discuss the case of a patient with end-of-life distress secondary to stage 4 astrocytoma that received PAT through Health Canada's Special Access Program. The patient had a positive response to PAT without adverse events. Standard treatment for existential distress is often inefficacious and PAT is rarely available, especially for patients with brain cancer. We highlight the importance of making PAT more available as many patients with unresolved existential distress resort to medical assistance in dying without ever knowing of the existence of PAT. PAT was effective in partially alleviating the patient's existential distress. Access to PAT needs to be expanded urgently.
在过去十年中，裸盖菇素辅助疗法（PAT）作为一种治疗存在性困扰的方法，在姑息治疗中受到了关注。脑癌患者被排除在研究之外，但他们与其他患有癌症相关心理困扰的患者一样，有从中受益的可能。在本报告中，我们讨论了一名因4期星形细胞瘤而处于临终困扰的患者的案例，该患者通过加拿大卫生部的特殊准入计划接受了PAT治疗。患者对PAT治疗反应良好，未出现不良事件。存在性困扰的标准治疗往往无效，而且PAT很少可用，尤其是对于脑癌患者。我们强调了增加PAT可及性的重要性，因为许多存在性困扰未得到解决的患者在根本不知道PAT存在的情况下求助于医疗协助死亡。PAT在部分缓解患者的存在性困扰方面是有效的。迫切需要扩大PAT的可及范围。
