Kedem J, Talafih K, Weiss H R
Eur J Pharmacol. 1985 May 28;112(1):47-55. doi: 10.1016/0014-2999(85)90237-7.
In eight open-chest anesthetized dogs, nitroglycerin (10 micrograms/kg per min) was infused intravenously for 2 h, beginning 10 min following ligation of the left anterior descending coronary artery. Oxygen supply, (radioactive microspheres), extraction (microspectrophotometry) and consumption were determined in subepicardial and subendocardial regions of both ischemic and non-ischemic myocardium, and compared to eight control hearts. In control, coronary occlusion reduced both subepicardial and subendocardial blood flow by 49.5% and 79.5% respectively. In the presence of nitroglycerin, depression of blood flow to the occluded regions was significantly less marked (-79.5% in control and -26.6% in the nitroglycerin group in the subendocardium). O2 extraction was significantly lowered by nitroglycerin in all areas. Regional O2 consumption was significantly lower in the control occluded than non-occluded regions; no regional O2 consumption differences were observed following nitroglycerin. In the occluded regions, nitroglycerin reduced the number of veins with very low O2 saturation. It is concluded that nitroglycerin improves the O2 supply/consumption balance in ischemia by redistribution of blood flow and possibly by alterations in local O2 consumption.
在八只开胸麻醉犬中，于左前降支冠状动脉结扎10分钟后开始静脉输注硝酸甘油（10微克/千克每分钟），持续2小时。通过放射性微球测定缺血和非缺血心肌的心外膜下和心内膜下区域的氧供应，通过显微分光光度法测定氧摄取和氧消耗，并与八个对照心脏进行比较。在对照组中，冠状动脉闭塞使心外膜下和心内膜下血流分别减少49.5%和79.5%。在使用硝酸甘油的情况下，闭塞区域的血流减少明显减轻（心内膜下对照组为-79.5%，硝酸甘油组为-26.6%）。硝酸甘油使所有区域的氧摄取显著降低。对照组闭塞区域的局部氧消耗明显低于非闭塞区域；使用硝酸甘油后未观察到局部氧消耗差异。在闭塞区域，硝酸甘油减少了氧饱和度极低的静脉数量。得出的结论是，硝酸甘油通过血流再分布以及可能通过局部氧消耗的改变来改善缺血时的氧供应/消耗平衡。
