有胆汁吗？母乳胆酸影响诺如病毒感染。

Got bile? Breastmilk bile acids influence norovirus infection.

机构信息

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Cell Host Microbe. 2024 Sep 11;32(9):1457-1459. doi: 10.1016/j.chom.2024.08.001.

DOI:10.1016/j.chom.2024.08.001

Abstract

Breastfeeding provides infection protection for several pathogens but not for noroviruses. Mechanisms explaining this discrepancy have been unclear. In this issue of Cell Host & Microbe, Peiper et al. demonstrate that while breastmilk protects mice from intestinal damage, it promotes neonatal murine norovirus infection due to maternal-derived bile acids..

摘要

母乳喂养为多种病原体提供感染保护，但不能预防诺如病毒。解释这种差异的机制尚不清楚。在本期《细胞宿主与微生物》中，Peiper 等人表明，尽管母乳可以保护小鼠免受肠道损伤，但由于母乳中的胆酸来源于母体，它会促进新生鼠诺如病毒的感染。