Harzic M, Girard-Pipau F, Halphen M, Ferchal F, Pérol Y, Rambaud J C
Gastroenterol Clin Biol. 1985 Jun-Jul;9(6-7):472-9.
Intestinal flora was explored in twelve patients affected with alpha-chain disease at different stages (stage A: 2 cases; stage B: 6 cases; stage C: 4 cases). Bacterial overgrowth in the jejunum was observed in 11 cases, but intestinal flora was diverse and no one species was always present; although a 3-month oral antibiotic treatment induced complete remission in one patient (stage A) it was not possible to demonstrate any pathogenic bacterial species. Intestinal lambliasis was present in 40 p. 100 of cases. Virologic studies were negative. At stages A and B of the disease, antibiotic treatment was able to improve malabsorption and/or plasma protein digestive losses in 62 p. 100 of cases; this effect seemed related to the reduction of the bacterial flora and to giardiasis eradication.
对12例处于不同阶段的α链病患者（A期：2例；B期：6例；C期：4例）的肠道菌群进行了研究。11例患者观察到空肠细菌过度生长，但肠道菌群多样，没有一种细菌总是存在；尽管一名患者（A期）接受3个月的口服抗生素治疗后完全缓解，但无法证实存在任何致病细菌种类。40%的病例存在肠道贾第虫病。病毒学研究为阴性。在疾病的A期和B期，62%的病例抗生素治疗能够改善吸收不良和/或血浆蛋白消化损失；这种效果似乎与细菌菌群的减少和贾第虫病的根除有关。
