Department of Nuclear Medicine, King Hussein Cancer Center, Amman, Jordan;
School of Medicine, University of Jordan, Amman, Jordan.
J Nucl Med. 2024 Oct 1;65(10):1533-1539. doi: 10.2967/jnumed.124.268049.
This study evaluates the diagnostic utility of PET/MRI for primary, locoregional, and nodal head and neck squamous cell carcinoma (HNSCC) through systematic review and metaanalysis. A systematic search was conducted using PubMed and Scopus to identify studies on the diagnostic accuracy of PET/MRI for HNSCC. The search included specific terms and excluded nonhybrid PET/MRI studies, and those with a sample size of fewer than 10 patients were excluded. In total, 15 studies encompassing 638 patients were found addressing the diagnostic test accuracy for PET/MRI within the chosen subject domain. Squamous cell carcinoma of the nasopharynx was the most observed HNSCC subtype ( = 198). The metaanalysis included 12 studies, with pooled sensitivity and specificity values of 93% and 95% per patient for primary disease evaluation, 93% and 96% for locoregional evaluation, and 89% and 98% per lesion for nodal disease detection, respectively. An examination of a subset of studies comparing PET/MRI against PET/CT or MRI alone for evaluating nodal and locoregional HNSCC found that PET/MRI may offer slightly higher accuracy than other modalities. However, this difference was not statistically significant. PET/MRI has excellent potential for identifying primary, locoregional, and nodal HNSCC.
本研究通过系统评价和荟萃分析评估了 PET/MRI 对原发性、局部区域和淋巴结头颈部鳞状细胞癌（HNSCC）的诊断效用。使用 PubMed 和 Scopus 进行了系统搜索，以确定关于 PET/MRI 对头颈部鳞状细胞癌诊断准确性的研究。搜索包括特定术语，并排除了非混合 PET/MRI 研究，以及样本量少于 10 名患者的研究。总共发现了 15 项研究，涵盖了所选主题领域内的 638 名患者，涉及 PET/MRI 的诊断测试准确性。鼻咽部鳞状细胞癌是观察到的最多的 HNSCC 亚型（= 198）。荟萃分析包括 12 项研究，对原发性疾病评估的汇总敏感性和特异性值分别为 93%和 95%/患者，对局部区域评估的汇总敏感性和特异性值分别为 93%和 96%，对淋巴结疾病检测的汇总敏感性和特异性值分别为 89%和 98%/病变。对比较 PET/MRI 与 PET/CT 或 MRI 单独评估淋巴结和局部区域 HNSCC 的一组研究进行的检查发现，PET/MRI 可能比其他方式提供稍高的准确性。然而，这种差异没有统计学意义。PET/MRI 对头颈部鳞状细胞癌的原发性、局部区域和淋巴结的识别具有优异的潜力。
