Chen Chaohu, Fan Guangrui, Li Pan, Yang Enguang, Jing Suoshi, Shi Yibo, Gong Yuwen, Zhang Luyang, Wang Zhiping
Institute of Urology, Lanzhou University Second Hospital, Chengguan District, No.82 Linxia Road, Lanzhou, 730030, People's Republic of China.
Gansu Province Clinical Research Center for Urinary System Disease, Lanzhou, People's Republic of China.
Clin Transl Oncol. 2025 Apr;27(4):1695-1711. doi: 10.1007/s12094-024-03694-z. Epub 2024 Sep 12.
It is well established that smoking is the most significant risk factor for bladder cancer, yet the impact of smoking on the recurrence and progression of non-muscle-invasive bladder cancer (NMIBC) remains a contentious issue.
To review all relevant literature published to date, providing a comprehensive assessment of the effects of smoking on the recurrence and progression of NMIBC, thereby offering a basis for smoking cessation management in NMIBC patients.
A search was conducted for all relevant literature published up to April 2024 in PubMed, Web of Science, and Embase databases. The existing literature results and deficiencies were analyzed, and the gaps in understanding between different studies were highlighted, with recommendations for future research.
A total of 24 studies were included in this work. Among them, 14 studies suggested that smoking promotes the recurrence and progression of NMIBC, while another 10 studies concluded that smoking has no effect on the recurrence and progression of NMIBC patients.
Our research indicates that smoking increases the risk of recurrence and progression in NMIBC patients, and quitting smoking can improve health-related quality of life. High-quality, large-sample prospective cohort studies (or randomized controlled studies) are still needed in the future.
吸烟是膀胱癌最重要的危险因素，这一点已得到充分证实，但吸烟对非肌层浸润性膀胱癌（NMIBC）复发和进展的影响仍是一个有争议的问题。
回顾迄今为止发表的所有相关文献，全面评估吸烟对NMIBC复发和进展的影响，从而为NMIBC患者的戒烟管理提供依据。
在PubMed、科学网和Embase数据库中检索截至2024年4月发表的所有相关文献。分析现有文献结果和不足，突出不同研究之间理解上的差距，并提出未来研究建议。
本研究共纳入24项研究。其中，14项研究表明吸烟会促进NMIBC的复发和进展，而另外10项研究得出结论，吸烟对NMIBC患者的复发和进展没有影响。
我们的研究表明，吸烟会增加NMIBC患者复发和进展的风险，戒烟可以改善健康相关生活质量。未来仍需要高质量、大样本的前瞻性队列研究（或随机对照研究）。
