Huang Zhihui, Yoo Koo Han, Li Duohui, Yu Qingxin, Ye Luxia, Wei Wuran
Operating Room, West China Hospital, Sichuan University, Chengdu, China.
West China School of Nursing, Sichuan University, Chengdu, China.
Discov Oncol. 2024 Sep 12;15(1):437. doi: 10.1007/s12672-024-01299-0.
Ribosomal RNA Processing 8 (RRP8) is a gene associated with RNA modification and has been implicated in the development of several types of tumors in recent research. Nevertheless, the biological importance of RRP8 in pan-cancer has not yet been thoroughly and comprehensively investigated.
In this study, we conducted an analysis of various public databases to investigate the biological functions of RRP8. Our analysis included examining its correlation with pan-cancer prognosis, heterogeneity, stemness, immune checkpoint genes, and immune cell infiltration. Furthermore, we utilized the GDSC and CTRP databases to assess the sensitivity of RRP8 to small molecule drugs.
Our findings indicate that RRP8 exhibits differential expression between tumor and normal samples, particularly impacting the prognosis of various cancers such as Adrenocortical carcinoma (ACC) and Kidney Chromophobe (KICH). The expression of RRP8 is intricately linked to tumor heterogeneity and stemness markers. Additionally, RRP8 shows a positive correlation with the presence of tumor-infiltrating cells, with TP53 being the predominant mutated gene in these malignancies.
Our findings suggest that RRP8 may serve as a potential prognostic marker and therapeutic target in a variety of cancer types.
核糖体RNA加工8（RRP8）是一种与RNA修饰相关的基因，近期研究表明它与多种肿瘤的发生发展有关。然而，RRP8在泛癌中的生物学重要性尚未得到全面深入的研究。
在本研究中，我们对多个公共数据库进行了分析，以探究RRP8的生物学功能。我们的分析包括研究其与泛癌预后、异质性、干性、免疫检查点基因以及免疫细胞浸润的相关性。此外，我们利用GDSC和CTRP数据库评估RRP8对小分子药物的敏感性。
我们的研究结果表明，RRP8在肿瘤样本和正常样本之间存在差异表达，尤其对肾上腺皮质癌（ACC）和肾嫌色细胞癌（KICH）等多种癌症的预后产生影响。RRP8的表达与肿瘤异质性和干性标志物密切相关。此外，RRP8与肿瘤浸润细胞的存在呈正相关，其中TP53是这些恶性肿瘤中主要的突变基因。
我们的研究结果表明，RRP8可能是多种癌症类型中潜在的预后标志物和治疗靶点。
