TUBITAK Marmara Research Center, Life Sciences, TUBITAK, Kocaeli, Turkey.
Molecular Biology and Genetics, Institute of Sciences, Yildiz Technical University, Istanbul, Turkey.
J Cell Mol Med. 2024 Sep;28(17):e70030. doi: 10.1111/jcmm.70030.
The aim of this study was to determine the antiviral activity of cannabidiol (CBD) against SARS-CoV-2 infection. CBD is the second most studied cannabinoid obtained from Cannabis plants. We investigated the potential use of CBD, which has so far proven to have a positive effect on different diseases, in the SARS-CoV-2 infection. To test this, in vivo studies were carried out using K18-hACE2 transgenic mice. To reveal the potential therapeutic effect of the CBD at the histopathological and molecular level challenge experiments were performed. The study was designed with two groups (n = 10) and in the treatment group animals were infected with SARS-CoV-2 virus strain B.1.1.7 alpha before the administration of CBD. While the disease progressed and resulted in death in the control group that was infected by the virus alone, it was observed that the infection slowed down and the survival rate increased in the mice treated with CBD along with the virus. In this study, K18-hACE2 transgenic mice infected with the wild SARS-CoV-2 virus were used to investigate and prove the antiviral activity of CBD.
本研究旨在确定大麻二酚（CBD）对 SARS-CoV-2 感染的抗病毒活性。CBD 是从大麻植物中提取的第二大研究最多的大麻素。我们研究了 CBD 的潜在用途，迄今为止，CBD 已被证明对多种疾病有积极影响，在 SARS-CoV-2 感染中。为了验证这一点，我们使用 K18-hACE2 转基因小鼠进行了体内研究。为了在组织病理学和分子水平上揭示 CBD 的潜在治疗效果，进行了挑战实验。该研究设计了两组（n=10），在治疗组中，动物在感染 SARS-CoV-2 病毒株 B.1.1.7 alpha 之前给予 CBD。虽然在对照组中，病毒单独感染导致疾病进展并导致动物死亡，但观察到 CBD 与病毒一起治疗的小鼠感染减慢，存活率提高。在这项研究中，使用 K18-hACE2 转基因小鼠感染野生 SARS-CoV-2 病毒，以研究和证明 CBD 的抗病毒活性。
