Liu Yin-Zhi, Zhang Rong, Xie Jing-Jing, Guo Qiong, Zhan Cai-Xia, Chen Meng-Yu, Li Jun-Shuai, Peng Xiao-Ming
Department of Neonatology, Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha 410007, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2024;26(9):986-988. doi: 10.7499/j.issn.1008-8830.2405123.
Patient 1, a 12-day-old female infant, presented with fever, cough, dyspnea, and elevated infection markers, requiring respiratory support. Metagenomic next-generation sequencing (mNGS) of blood and bronchoalveolar lavage fluid revealed (LP), leading to diagnoses of LP pneumonia and LP sepsis. The patient was treated with erythromycin for 15 days and azithromycin for 5 days, resulting in recovery and discharge. Patient 2, an 11-day-old female infant, presented with dyspnea, fever, elevated infection markers, and multiple organ dysfunction, requiring mechanical ventilation. mNGS of blood and cerebrospinal fluid indicated LP, leading to diagnoses of LP pneumonia, LP sepsis, and LP intracranial infection. The patient was treated with erythromycin for 19 days and was discharged after recovery. Neonatal LP pneumonia lacks specific clinical symptoms, and azithromycin is the preferred antimicrobial agent. The use of mNGS can provide early and definitive diagnosis for severe neonatal pneumonia of unknown origin.
病例1，一名12日龄女婴，出现发热、咳嗽、呼吸困难及感染指标升高，需要呼吸支持。对血液和支气管肺泡灌洗液进行宏基因组下一代测序（mNGS）发现了（嗜肺军团菌，LP），从而诊断为LP肺炎和LP败血症。该患者接受了15天的红霉素治疗和5天的阿奇霉素治疗，最终康复出院。病例2，一名11日龄女婴，出现呼吸困难、发热、感染指标升高及多器官功能障碍，需要机械通气。对血液和脑脊液进行mNGS检测显示为LP，从而诊断为LP肺炎、LP败血症和LP颅内感染。该患者接受了19天的红霉素治疗，康复后出院。新生儿LP肺炎缺乏特异性临床症状，阿奇霉素是首选抗菌药物。mNGS的应用可为病因不明的重症新生儿肺炎提供早期明确诊断。
