Fan Ji-Qiang, Li Yanshuang, Wu Xu Wen, Li Man-Bo
Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei, 230601, P. R. China.
School of Chemistry and Material Engineering, Fuyang Normal University, Fuyang, Anhui 236037, P. R. China.
Angew Chem Int Ed Engl. 2025 Jan 2;64(1):e202413861. doi: 10.1002/anie.202413861. Epub 2024 Oct 30.
Constructing structurally robust and catalytically active metal nanoclusters for catalyzing multi-component reactions is an interesting while challenging task. Inspired by Lewis acid and Lewis base catalysis, we realized the combination of both Lewis acid and Lewis base sites on the surface of a stable gold nanocluster AuCd. The catalytic potential of AuCd in four-component Ugi reaction was explored, demonstrating high activity and exceptional recyclability. In-depth mechanism studies indicate that the catalytic synergy of the Lewis acid/base pair is crucial for the high efficiency of AuCd-catalyzed Ugi reaction. Bearing the stable structure, multiple activation sites and hierarchical chirality, AuCd is expected to display further interesting catalytic performance such as asymmetric catalysis.
构建结构坚固且具有催化活性的金属纳米团簇以催化多组分反应是一项有趣但具有挑战性的任务。受路易斯酸和路易斯碱催化的启发，我们在稳定的金纳米团簇AuCd表面实现了路易斯酸和路易斯碱位点的结合。探索了AuCd在四组分乌吉反应中的催化潜力，证明了其高活性和出色的可回收性。深入的机理研究表明，路易斯酸/碱对的催化协同作用对于AuCd催化乌吉反应的高效率至关重要。由于具有稳定的结构、多个活化位点和分级手性，AuCd有望展现出如不对称催化等更有趣的催化性能。
