幽门螺杆菌感染与接受减肥手术的肥胖患者的肝纤维化有关。
Helicobacter pylori infection is associated with liver fibrosis in patients with obesity undergoing bariatric surgery.
作者信息
Córdova-Gallardo Jacqueline, Martínez-Sánchez Froylan David, Medina-Julio David, Rojano-Rodríguez Martin Edgardo, Romero-Loera Luz Sujey, Vargas-Agredano Romina, Méndez-Sánchez Nahum
机构信息
Facultad de Medicina Universidad Nacional Autonoma de Mexico Coyoacán Mexico.
Department of Hepatology Hospital General "Dr. Manuel Gea González" Tlalpan Mexico.
出版信息
JGH Open. 2024 Sep 12;8(9):e70023. doi: 10.1002/jgh3.70023. eCollection 2024 Sep.
BACKGROUND
Obesity is a significant risk factor for metabolic-associated steatotic liver disease (MASLD). The association between Helicobacter pylori (HP) infection and liver fibrosis has not been fully elucidated in patients with obesity and MASLD.
METHODS
This observational retrospective study included clinical and biochemical parameters of patients with obesity undergoing bariatric surgery. HP infection was confirmed by gastric endoscopy, and liver biopsies were performed during surgery. Bivariate and logistic regression analyses were employed to evaluate independent associations with liver fibrosis and steatosis by biopsy.
RESULTS
The mean age of the subjects was 42 ± 10 years, with 84.7% being women, and they had a mean BMI of 42.97 ± 7.56 kg/m2. Overall, 41.7% of patients had an HP infection. Multiple logistic regression models were conducted to assess the association between HP infection, liver steatosis, and fibrosis by biopsy. HP infection was independently associated with liver fibrosis [OR = 3.164 (95% CI 1.011-9.900)].
CONCLUSION
Biopsy findings associated HP infection with increased liver fibrosis.
背景
肥胖是代谢相关脂肪性肝病（MASLD）的重要危险因素。幽门螺杆菌（HP）感染与肥胖和MASLD患者肝纤维化之间的关联尚未完全阐明。
方法
这项观察性回顾性研究纳入了接受减肥手术的肥胖患者的临床和生化参数。通过胃镜检查确认HP感染，并在手术期间进行肝活检。采用双变量和逻辑回归分析来评估活检中与肝纤维化和脂肪变性的独立关联。
结果
受试者的平均年龄为42±10岁，其中84.7%为女性，平均体重指数为42.97±7.56kg/m²。总体而言，41.7%的患者有HP感染。进行了多个逻辑回归模型以评估HP感染、肝脂肪变性和活检纤维化之间的关联。HP感染与肝纤维化独立相关[比值比=3.164（95%置信区间1.011-9.900）]。
结论
活检结果表明HP感染与肝纤维化增加有关。
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