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新型冠状病毒肺炎后肺炎患者中成纤维细胞活化蛋白特异性正电子发射断层扫描/计算机断层扫描的评估

Evaluation of fibroblast activation protein-specific PET/CT in a patient with post-COVID pneumonitis.

作者信息

Musameh Khaled, O'Brien Shane, Mehboob Roshane, Butler Thomas, Cunningham Zara, Buckley Carol, Atzinger Armin, Kuwert Torsten, Mitchell Patrick, Donnelly Seamas C

机构信息

Department of Clinical Medicine School of Medicine, Trinity College Dublin Dublin Ireland.

Department of Nuclear Medicine Friedrich-Alexander University Erlangen and University Hospital Erlangen Erlangen Germany.

出版信息

Respirol Case Rep. 2024 Sep 12;12(9):e01446. doi: 10.1002/rcr2.1446. eCollection 2024 Sep.

Abstract

Coronavirus disease 2019 (COVID-19) often leads to a spectrum of pulmonary complications, including interstitial lung disease (ILD) with the potential for fibrotic sequelae. Assessing the presence of ongoing active inflammation versus established residual fibrosis as a result of lung parenchymal injury and repair in these patients is a clinical challenge. Better understanding of the disease process is crucial for guiding appropriate therapeutic strategies. We aim to investigate the use of positron emission tomography / computer tomography (PET/CT) scans and their role in diagnosing interstitial pneumonitis (IP) post COVID infections.

摘要

2019冠状病毒病(COVID-19)常导致一系列肺部并发症,包括间质性肺病(ILD),并有发生纤维化后遗症的可能。评估这些患者因肺实质损伤和修复而出现的持续活动性炎症与已形成的残余纤维化,是一项临床挑战。更好地了解疾病过程对于指导适当的治疗策略至关重要。我们旨在研究正电子发射断层扫描/计算机断层扫描(PET/CT)的使用及其在诊断COVID感染后间质性肺炎(IP)中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de4/11391468/98e20a4ac17e/RCR2-12-e01446-g001.jpg

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