Li Yanwei, Wang Jing, Wang ChengLiang, Chen Li
Department of Pharmacy, People's Hospital of Ganzi Tibetan Autonomous Prefecture, Kangding, Sichuan, China.
Department of Pharmacy, Sichuan Mianyang 404 Hospital, Mianyang, Sichuan, China.
Front Med (Lausanne). 2024 Aug 29;11:1437376. doi: 10.3389/fmed.2024.1437376. eCollection 2024.
This study utilizes the FDA Adverse Event Reporting System (FAERS) to investigate adverse drug event (ADE) signals linked to quinolones use (ciprofloxacin, moxifloxacin, levofloxacin, ofloxacin) in minors, offering insights for clinical use.
Minors were categorized into four age groups. ADE reports for these quinolones from the first quarter of 2015 to the third quarter of 2023 were extracted from the FAERS database. Data analysis used reporting odds ratio (ROR) and the MHRA method.
Most ADE cases in minors involved ciprofloxacin (575)and levofloxacin (477). In the infant group, various injury, poisoning, and procedural complication events were more frequently associated with ciprofloxacin, levofloxacin, and moxifloxacin (19.83%, 31.25%, and 100.00%, respectively). In the preschool children group, psychiatric disorders were more frequently reported with levofloxacin and ofloxacin use (59.00% and 47.62%, respectively). Ocular disorders were notably associated with moxifloxacin in the children group (62.50%), In the adolescent group, more gastrointestinal diseases occurred with ciprofloxacin (12.96%).
ADE occurrence with quinolones in minors varies by age. Strict adherence to indications, rational use, avoiding prolonged use, and monitoring for short-term reactions are essential. Enhanced monitoring of interactions and drug education are crucial to reducing ADE.
本研究利用美国食品药品监督管理局不良事件报告系统（FAERS）调查与未成年人使用喹诺酮类药物（环丙沙星、莫西沙星、左氧氟沙星、氧氟沙星）相关的药物不良事件（ADE）信号，为临床用药提供见解。
将未成年人分为四个年龄组。从FAERS数据库中提取2015年第一季度至2023年第三季度这些喹诺酮类药物的ADE报告。数据分析采用报告比值比（ROR）和MHRA方法。
未成年人中大多数ADE病例涉及环丙沙星（575例）和左氧氟沙星（477例）。在婴儿组中，各种损伤、中毒和手术并发症事件与环丙沙星、左氧氟沙星和莫西沙星的关联更为频繁（分别为19.83%、31.25%和100.00%）。在学龄前儿童组中，使用左氧氟沙星和氧氟沙星时精神障碍的报告更为频繁（分别为59.00%和47.62%）。在儿童组中，眼部疾病与莫西沙星显著相关（62.50%）。在青少年组中，环丙沙星导致更多胃肠道疾病（12.96%）。
未成年人使用喹诺酮类药物时ADE的发生因年龄而异。严格遵循适应证、合理用药、避免长期使用并监测短期反应至关重要。加强对相互作用的监测和药物教育对于减少ADE至关重要。
