Ma Xinru, Deng Kun, Sun Yingnan, Wu Minghua
The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan, China.
The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
Front Neurosci. 2024 Aug 29;18:1408306. doi: 10.3389/fnins.2024.1408306. eCollection 2024.
BACKGROUND: Recently, cancer neuroscience has become the focus for scientists. Interactions between the nervous system and cancer (both systemic and local) can regulate tumorigenesis, progression, treatment resistance, compromise of anti-cancer immunity, and provocation of tumor-promoting inflammation. We assessed the related research on cancer neuroscience through bibliometric analysis and explored the research status and hotspots from 2020 to 2024. METHODS: Publications on cancer neuroscience retrieved from the Web of Science Core Collection. CiteSpace, VOSviewer, and Scimago Graphica were used to analyze and visualize the result. RESULTS: A total of 744 publications were retrieved, with an upward trend in the overall number of articles published over the last 5 years. As it has the highest number of publications ( = 242) and citations (average 13.63 citations per article), the United States holds an absolute voice in the field of cancer neuroscience. The most productive organizations and journals were Shanghai Jiaotong University ( = 24) and Cancers ( = 45), respectively. Monje M (H-index = 53), Hondermarck H (H-index = 42), and Amit M (H-index = 39) were the three researchers who have contributed most to the field. From a global perspective, research hotspots in cancer neuroscience comprise nerve/neuron-tumor cell interactions, crosstalk between the nervous system and other components of the tumor microenvironment (such as immune cells), as well as the impact of tumors and tumor therapies on nervous system function. CONCLUSION: The United States and European countries are dominating the field of cancer neuroscience, while developing countries such as China are growing rapidly but with limited impact. The next focal point in this field is likely to be neurotrophic factors. Cancer neuroscience is still in its infancy, which means that many of the interactions and mechanisms between the nervous system and cancer are not yet fully understood. Further investigation is necessary to probe the interactions of the nervous system with cancer cell subpopulations and other components of the tumor microenvironment.
背景：近年来，癌症神经科学已成为科学家们关注的焦点。神经系统与癌症（包括全身和局部）之间的相互作用可调节肿瘤发生、进展、治疗抗性、抗癌免疫功能受损以及促肿瘤炎症的激发。我们通过文献计量分析评估了癌症神经科学的相关研究，并探讨了2020年至2024年的研究现状和热点。 方法：从科学引文索引核心合集中检索关于癌症神经科学的出版物。使用CiteSpace、VOSviewer和Scimago Graphica对结果进行分析和可视化。 结果：共检索到744篇出版物，过去5年发表的文章总数呈上升趋势。美国在癌症神经科学领域拥有绝对话语权，其发表的文章数量最多（242篇），被引频次也最高（平均每篇文章被引13.63次）。发文量最多的机构和期刊分别是上海交通大学（24篇）和《癌症》（45篇）。Monje M（H指数 = 53）、Hondermarck H（H指数 = 42）和Amit M（H指数 = 39）是对该领域贡献最大的三位研究人员。从全球范围来看，癌症神经科学的研究热点包括神经/神经元 - 肿瘤细胞相互作用、神经系统与肿瘤微环境其他成分（如免疫细胞）之间的串扰，以及肿瘤和肿瘤治疗对神经系统功能的影响。 结论：美国和欧洲国家在癌症神经科学领域占据主导地位，而中国等发展中国家发展迅速但影响力有限。该领域的下一个重点可能是神经营养因子。癌症神经科学仍处于起步阶段，这意味着神经系统与癌症之间的许多相互作用和机制尚未完全了解。有必要进一步研究神经系统与癌细胞亚群以及肿瘤微环境其他成分之间的相互作用。
Front Neurosci. 2024-8-29
World J Clin Oncol. 2023-11-24
Front Neurosci. 2023-6-15
Front Cell Infect Microbiol. 2022
Hum Vaccin Immunother. 2025-12
J Clin Invest. 2023-12-15
Nature. 2023-6
Nat Rev Cancer. 2023-5
Cancer Metastasis Rev. 2023-6
Cancer Cell. 2023-3-13
J Exp Clin Cancer Res. 2022-12-15
Zotero 插件
