Huang Zhilan, Xie Tingyi, Xie Wei, Chen Zhuni, Wen Zhiyuan, Yang Lin
The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.
Department of Respiratory Medicine, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
Front Oncol. 2024 Jul 31;14:1428018. doi: 10.3389/fonc.2024.1428018. eCollection 2024.
Lung cancer (LC) is one of the most common malignant tumors in the world and the leading cause of cancer-related deaths, which seriously threatens human life and health as well as brings a heavy burden to the society. In recent years, the tumor microenvironment (TME) has become an emerging research field and hotspot affecting tumor pathogenesis and therapeutic approaches. However, to date, there has been no bibliometric analysis of lung cancer and the tumor microenvironment from 2014 to 2023.This study aims to comprehensively summarize the current situation and development trends in the field from a bibliometric perspective.
The publications about lung cancer and the tumor microenvironment from 2014 to 2023 were extracted from the Web of Science Core Collection (WoSCC). The Microsoft Excel, Origin, R-bibliometrix, CiteSpace, and VOSviewer software are comprehensively used to scientifically analyze the data.
Totally, 763 publications were identified in this study. A rapid increase in the number of publications was observed after 2018. More than 400 organizations published these publications in 36 countries or regions. China and the United States have significant influence in this field. Zhou, CC and Frontiers in Immunology are the most productive authors and journals respectively. Besides, the most frequently cited references were those on lung cancer pathogenesis, clinical trials, and treatment modalities. It suggests that novel lung cancer treatment models mainly based on the TME components, such as cancer-associated fibroblasts (CAFs) may lead to future research trends.
The field of lung cancer and the tumor microenvironment research is still in the beginning stages. Gene expression, molecular pathways, therapeutic modalities, and novel detection technologies in this field have been widely studied by researchers. This is the first bibliometric study to comprehensively summarize the research trend and development regarding lung cancer and tumor microenvironment over the last decade. The result of our research provides the updated perspective for scholars to understand the key information and cutting-edge hotspots in this field, as well as to identify future research directions.
肺癌是全球最常见的恶性肿瘤之一，也是癌症相关死亡的主要原因，严重威胁人类生命健康，给社会带来沉重负担。近年来，肿瘤微环境（TME）已成为影响肿瘤发病机制和治疗方法的新兴研究领域和热点。然而，迄今为止，尚未有对2014年至2023年肺癌与肿瘤微环境的文献计量分析。本研究旨在从文献计量学角度全面总结该领域的现状和发展趋势。
从科学引文索引核心合集（WoSCC）中提取2014年至2023年关于肺癌与肿瘤微环境的出版物。综合使用Microsoft Excel、Origin、R-bibliometrix、CiteSpace和VOSviewer软件对数据进行科学分析。
本研究共识别出763篇出版物。2018年后出版物数量迅速增加。36个国家或地区的400多个组织发表了这些出版物。中国和美国在该领域具有重大影响力。周，CC和《免疫学前沿》分别是发文量最多的作者和期刊。此外，被引用频率最高的参考文献是关于肺癌发病机制、临床试验和治疗方式的文献。这表明主要基于肿瘤微环境成分（如癌症相关成纤维细胞（CAFs））的新型肺癌治疗模型可能引领未来研究趋势。
肺癌与肿瘤微环境研究领域仍处于起步阶段。该领域的基因表达、分子途径、治疗方式和新型检测技术已受到研究人员的广泛研究。这是首次全面总结过去十年肺癌与肿瘤微环境研究趋势和发展的文献计量学研究。我们的研究结果为学者们了解该领域的关键信息和前沿热点以及确定未来研究方向提供了最新视角。
